The second most significant cause of cancer-related mortality and morbidity in the United States is colorectal cancer (CRC), third diagnosed malignancy. People over 50 have an increased risk CRC everywhere world. Genetic environmental factors significantly influence development. Early detection critical treatment prevention CRC. population’s incidence rate currently reduced by screening techniq...

Abstract In order to alter the solubility and bioavailability of various functional lipids plant essential oils (EOs), it is possible prepare their oil in water (O/W) nanoemulsions. Thyme O/W nanoemulsions were prepared under subcritical conditions (at 120°C pressure 1.5 atm for 2 h), using Tween 20, 80, saponin, Arabic gum, xanthan sodium caseinate as emulsifiers. Results indicated that with m...

The objective of present work was development of felodipine nano emulsion formulations using sesame oil as sole lipid phase by high pressure homogenization technique. A combination of non-ionic surfactants was used based on HLB (Hydrophilic lipophilic balance) values. The resultant nano emulsions were characterized for particle size, zeta potential. The particle size for the optimized nano emul...

BACKGROUND Nanoemulsions have practical application in a multitude of commercial areas, such as the chemical, pharmaceutical and cosmetic industries. Cosmetic industries use rice bran oil in sunscreen formulations, anti ageing products and in treatments for skin diseases. The aim of this study was to create rice bran oil nanoemulsions using low energy emulsification methods and to evaluate thei...

1Nanotechnology Laboratory, Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal, Andhra Pradesh, India 506009 A b s t r a c t Docetaxel is currently used in treatment of breast and ovarian cancers, administered in the form of parenteral IV infusion. Lipid nanoemulsion (LNE) delivery system is biocompatible, biodegradable and easy to prepare....

Nanocarriers delivering prodrugs are a way of improving in vivo effectiveness and efficiency. For therapeutic efficacy, the prodrug must hydrolyze to its parent drug after administration. Based on the fact that the hydrolysis is impeded by steric hindrance and improved by sufficient polarity, in this study, we proposed the PTX-S-S-VE, the conjugation of paclitaxel (PTX) to vitamin E (VE) throug...

Recent studies have shown the effect of soy isoflavones in preventing skin photoaging and photocarcinogenesis, especially for genistein (GEN). Nanoemulsions have been proposed as a delivery system for GEN administration due to the low water solubility of this isoflavone. This article describes the validation of an isocratic liquid chromatography method to determine GEN in porcine ear skin layer...

We report the coexistence of stress-bearing percolation with arrested phase separation in a colloidal system of thermoresponsive nanoemulsions spanning a broad range of volume fractions (0.10 ≤ ϕ ≤ 0.33) and temperatures (22 °C ≤ T ≤ 65 °C). Here, gelation is driven by short-range interdroplet polymer bridging at elevated temperatures. Direct visualization of the gel microstructure shows that n...

Several obstacles are encountered in conventional chemotherapy, such as drug toxicity and poor stability. Nanotechnology is envisioned as a strategy to overcome these effects and to improve anticancer therapy. Nanoemulsions comprise submicron emulsions composed of biocompatible lipids, and present a large surface area revealing interesting physical properties. Chalcones are flavonoid precursors...

Topical ophthalmic delivery of active ingredients can be achieved using cationic nanoemulsions. In the last decade, Novagali Pharma has successfully developed and marketed Novasorb, an advanced pharmaceutical technology for the treatment of ophthalmic diseases. This paper describes the main steps in the development of cationic nanoemulsions from formulation to evaluation in clinical trials. A m...