Glimepiride (GMP) is poorly water soluble drug, so solubility is the main constraint for its oral bioavailability. The aim of this study was to investigate the potential of cubosomes as lipid nanocarrier to improve the solubility and sustained action of Glimepiride. Glimepiride is one of the third generation sulfonylureas used for treatment of type 2 diabetes. The rationale of this study was to...

PEI GO The RNA interference (RNAi) technique, an effective method to inhibit protein expression by targeted cleavage of messenger RNA (mRNA), has made substantial progress since the fi rst demonstration of gene knockdown in mammalian cells. [ 1 ] Short interfering RNA (siRNA) induces specifi c silencing of targeted protein, thus offering signifi cant potential in overcoming multiple drug resist...

The recent development of light irradiation systems has facilitated the emergence of new therapies based on light-sensitive drugs. However, photosensitizers have a tendency to self-associate in physiologic environment, leading to a loss of their physical properties. Hence, nanometric formulations have been assessed, because this limits self-association and enables accumulation in solid tumors o...

P ancreatic cancer, one of the deadliest cancers, may lead to new treatments based on biotypes that are common to many cancers, according to Andrew Biankin, MBBS, Ph.D. , head of pancreatic research at the Garvan Institute of Medical Research in Sydney. “In the current system, the assumption is that cancers are more related to the organ of origin,” Biankin said, adding that using cancer biotype...

Introduction: The therapeutic potential of anandamide (AEA) for the neurological disorders may be negatively affected by its short half-life or poor solubility. The superior properties of carbon nanotubes (CNTs) for controlled drug delivery, prompted us to design AEA-CNTs complex and assess its effect in in vitro model of ischemic stroke. Methods: In this experimental study, a multi-walled CNTs...

Introduction: Carbon nanotubes (CNTs) have shown enormous potential in neuroscience. Nerve growth factor (NGF)-CNTs complex promotes the neuronal growth, however, the underlying mechanism(s) have remained elusive. Based on the interplay between NGF and the endocannabinoid system, involvement of the neuroprotective endocannabinoid, 2arachidonoyl glycerol (2-AG), was investigated in the mechanism...