The homophilic potential emerges as an important biological principle to boost the potency of immunoglobulins. Since homophilic antibodies in human and mouse sera exist prior environmental exposure, they are part of the natural antibody repertoire. Nevertheless, hemophilic properties are also identified in induced antibody repertoire. The use of homophilicity of antibodies in the adaptive immun...

Forty years ago, we started our quest for 'The Holy Grail' of understanding ventricular rate control and rhythm in atrial fibrillation (AF). We therefore studied the morphology and function of a wide range of mammalian hearts. From mouse to whale, we found that all hearts show similar structural and functional characteristics. This suggests that the mammalian heart remained well conserved durin...

The concept of software architecture is not new. Software designers have been working on architectures for many years. A bunch of consolidated wellengineered architectural solutions have already been produced and are now being used in everyday practice. Rather than inventing new solutions, research on software architectures is thus concentrating on providing a systematic organization of existin...

Bacteria have aggressive acquisition processes for iron, an essential nutrient. Siderophores are small iron chelators that facilitate cellular iron transport. The siderophore enterobactin is a triscatechol derivative of a cyclic triserine lactone. Studies of the chemistry, regulation, synthesis, recognition, and transport of enterobactin make it perhaps the best understood of the siderophore-me...

Extant research on open innovation (OI) offers no systematic insight of how and why firms differ regarding the extent to which they conduct OI activities. Whereas past theoretical contributions have focused on explaining the externalisation of R&D activities as a result of firm-external factors, we focus on explaining this externalisation as a result of firm-internal weaknesses, specifically, i...

Although binarization is considered passe, it still remains a highly popular research topic. In this paper we propose a rethinking of what binarization is. We introduce the notion of the visual archetype as the ideal form of any one document. Binarization can be defined as the restoration of the visual archetype for a class of images. This definition broadens the scope of what binarization mean...

Semantic interoperability of clinical standards is a major challenge in the eHealth across Europe, because this would allow healthcare professionals to manage the complete EHR of patient. Archetypes are considered a cornerstone to deliver fully interoperable EHRs. Our work is focused on the development of ontology-based methods and techniques for providing semantic interoperability between di e...

The semantic interoperability between health information systems is a major challenge to improve the quality of clinical practice and patient safety. In recent years many projects have faced this problem and provided solutions based on specific standards and technologies in order to satisfy the needs of a particular scenario. Most of such solutions cannot be easily adapted to new scenarios, thu...

OBJECTIVE To explore semantic search to improve management and user navigation in clinical archetype repositories. METHODS In order to support semantic searches across archetypes, an automated method based on SNOMED CT modularization is implemented to transform clinical archetypes into SNOMED CT extracts. Concurrently, query terms are converted into SNOMED CT concepts using the search engine ...