Chronic rhinitis (CR) is commonly divided into allergic (AR) and nonallergic (NAR). AR triggered by the immunoglobulin E (IgE)-mediated response to allergens, whereas NAR characterized absence of sensitization. Previous studies have demonstrated presence local IgE in nasal mucosa patients suffering from typical symptoms but without a history atopy positive allergen challenge (NAC). This conditi...

Histamine H(4) receptor (H(4)R)-deficient mice (H(4)R(-/-)), H(4)R antagonist-treated wild-type (WT) mice, and WT mice depleted of basophils failed to develop early (EPR) or late phase (LPR) nasal responses following allergen sensitization and challenge. Basophil transfer from WT but not H(4)R(-/-) mice restored the EPR and LPR in H(4)R(-/-) mice. Following passive sensitization with OVA-specif...

BACKGROUND House dust mites (HDMs) are a major cause of allergic rhinitis (AR) and asthma worldwide. Recent studies suggested that the allergen load presents seasonal modifications, giving rise to seasonal variation in nasal inflammation and symptoms. The aim of this study was to evaluate by nasal cytology whether nasal inflammation in mite-allergic patients changes with the seasons of the year...

Di Genova, Genoa, Italy. Background: The airways and the upper digestive tract have a common embrional origin, and in sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis or oral allergy syndrome). We investigated the possible functional connection between respiratory tract and upper digestive tract by means of specific oral allergen challenges. Methods...

Di Genova, Genoa, Italy. Background: The airways and the upper digestive tract have a common embrional origin, and in sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis or oral allergy syndrome). We investigated the possible functional connection between respiratory tract and upper digestive tract by means of specific oral allergen challenges. Methods...

Di Genova, Genoa, Italy. Background: The airways and the upper digestive tract have a common embrional origin, and in sensitized subjects they can respond to allergens with an immediate reaction (asthma, rhinitis or oral allergy syndrome). We investigated the possible functional connection between respiratory tract and upper digestive tract by means of specific oral allergen challenges. Methods...

BACKGROUND Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. OBJECTIVE The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate ...

Priming of circulating human eosinophils following late response to allergen challenge. D.J. Evans, M.A. Lindsay, B.J. O'Connor, P.J. Barnes. ©ERS Journals Ltd 1996. ABSTRACT: The eosinophil is recognized as an important effector cell in asthma. To investigate the role of eosinophils in the aetiology of asthma, we have examined whether peripheral blood eosinophils are primed following whole-lun...

BACKGROUND Allergen specific immunotherapy was known to be useful in the treatment of respiratory allergic disease. Local nasal immunotherapy (LNIT) offers advantages such as a good efficacy/safety ratio and a more convenient allergen delivery. The aim of this study was to assess the safety and clinical efficacy of a modified scheduling of LNIT in 32 children with allergic rhinitis due to Derma...

This study aimed to observe microvascular changes in the nasal mucosa of Sprague-Dawley (SD) rats with allergic rhinitis (AR) after persistent exposure to an allergen with fluticasone propionate (FP) treatment. Ninety healthy SD rats were randomly distributed into the control group (A, N = 30), the group with continued exposure to an allergen (B, N = 30), and FP treatment group (C, N = 30). The...