CYP2G2P is pseudogenized in humans because of two nonsense mutations (c.76C>T in exon 1 and c.382C>T in exon 3) in the putative coding region of the gene sequence, whereas mouse, rat, and rabbit CYP2Gs are expressed and functional in nasal mucosa. In this study, we assessed the intactness of CYP2G in a cynomolgus monkey, a macaque species important for drug metabolism studies because of its evo...

tory cellular infiltrate. Methods: In this study we investigated expression of selected chemokine receptors in human NP and non-affected human nasal mucosa and carried out a comparison with NP from allergic patients with aspirin intolerance. Biopsies of NP were obtained from 20 patients and 4 patients with NP and aspirin intolerance. Mucosal biopsy specimens of the inferior turbinate were obtai...

Regulatory T cells (Treg) play some important roles in allergic rhinitis. The most specific marker for Treg is FOXP3, a recently identified transcription factor that is essential for Treg development. In order to clarify the levels of Treg in allergic nasal mucosa, we studied the relationship between FOXP3-expressing cells and Th1-Th2 balance in nasal mucosa by means of immunohistochemistry. Hu...

Aujeszky's disease virus (ADV) is a well known neurotropic virus in pigs. In the present study the mechanism of spread of ADV along the maxillary nerve and the role of the viral envelope glycoproteins gC, gE and gI in this process was examined in pigs. The Ka parental strain of ADV and its gC-, gE- and gI-deleted mutants were inoculated intranasally in pigs, after which virus dissemination in t...

Temperatures of the brain, skin, and nasal mucosa were recorded along with the cortical electroencephalogram (EEG) in chaired, conscious pigtail monkeys at 25 degrees C air temperature. In undisturbed animals, skin temperatures ranged from 34 to 37 degrees C. When the animal was alerted by visual or auditory stimuli, temperatures on the extremities, tail, nose, ears, and nasal mucosa dropped ra...

Hyperbaric oxygen (HBO) therapy is becoming increasingly popular in the treatment of several pathologies, namely in vascular diseases. It is generally considered to be innocuous, with few restrictions. Thus, patients subjected to HBO therapy breath saturated oxygen at an elevated pressure. Since the respiratory mucosa comes into contact with this altered inhaled air, we decided to use light and...

In recent years, studies on the consistency between upper and lower airway inflammation have been receiving more attention; however, the function and mechanism of dendritic cells (DCs) in this context are still not clear. In the present research, we studied the function and mechanism of DCs in the consistency between the upper and lower airway inflammatory responses. CD80, CD86, interferon gamm...

tory cellular infiltrate. Methods: In this study we investigated expression of selected chemokine receptors in human NP and non-affected human nasal mucosa and carried out a comparison with NP from allergic patients with aspirin intolerance. Biopsies of NP were obtained from 20 patients and 4 patients with NP and aspirin intolerance. Mucosal biopsy specimens of the inferior turbinate were obtai...

tory cellular infiltrate. Methods: In this study we investigated expression of selected chemokine receptors in human NP and non-affected human nasal mucosa and carried out a comparison with NP from allergic patients with aspirin intolerance. Biopsies of NP were obtained from 20 patients and 4 patients with NP and aspirin intolerance. Mucosal biopsy specimens of the inferior turbinate were obtai...

Oxidative stress is considered as a major risk factor that contributes to increased lipid peroxidation and declined antioxidants in some degenerative diseases. Glycyrrhizin is widely used to cure allergic diseases due to its medicinal properties. In the present study, we evaluated the role of glycyrrhizin on lipid peroxidation and antioxidant status in the blood and nasal mucosa of allergic rhi...