We report a patient with nasopharyngeal cancer with long-term follow-up of more than 16 years after the first course of radiotherapy in 1981. He developed a lung metastasis in 1996 after having a second course of radiotherapy for neck recurrence in 1989. The patient was a 42-year-old man with a nasopharyngeal tumor and a fixed upper neck metastasis (T1N1M0), which was treated with definitive ra...

Four patients with nasopharyngeal malignancies were reported. The main symptom was diplopia due to abducens palsy in all patients; it was unilateral in three patients and bilateral in one. Skull tomographic evaluation was valuable for detecting nasopharyngeal malignancies. Histological examination of biopsy specimens from the nasopharynx confirmed these lesions to be squamous cell carcinoma in ...

PURPOSE To investigate the prognostic effect of the concentrations and clearance rates of plasma EBV DNA in metastatic/recurrent nasopharyngeal carcinoma (NPC). EXPERIMENTAL DESIGN Thirty relapsed and four previously nontreated metastatic NPC patients were treated according to the consensus guidelines of the head and neck cancer team in our hospital (i.v. chemotherapy first, followed by local...

UNLABELLED The nasopharyngeal carcinoma (NPC) is a rare cancer with a high incidence in Southern Asia. AIM To study the demographic, clinical, therapeutic, and prognostic factors of nasopharyngeal undifferentiated carcinoma in a reference service. MATERIALS AND METHODS A retrospective study was made of 46 patients from January 1998 to August 2000. The patients had no previous treatment and ...

Different specimens and techniques have been used in the diagnosis of carriers of Neisseria meningitidis, reflecting the uncertainty about the optimal diagnostic procedure. In the present investigation the culture yield of meningococci from throat specimens was compared to that from nasopharyngeal speimens in 178 persons: 44 carriers were diagnosed. All of them were detected by culture of throa...

IMPORTANCE Extracranial pituitary ectopia is an uncommon finding characterized by all or a portion of the pituitary gland situated in an aberrant location. Often these lesions come to clinical attention only once they begin to function abnormally or increase in size significantly. OBSERVATIONS We describe an incidentally noted, asymptomatic pedunculated nasopharyngeal lesion in a 13-month-old...

With the development of advanced imaging and radiation technologies, radiotherapy has been employed as the principal treatment approach for nasopharyngeal carcinoma (NPC). So far, a number of patients still suffer from the failure of this treatment due to the acquired radioresistance, but the underlying mechanisms are still poorly defined. In this study, we found that Twist1, participating in a...

Nasopharyngeal bursitis is a relatively rare syndrome characterized by a collection of symptoms that multidisciplinary specialists should be aware of. Here we present an audit of cases presenting to a rhinology clinic over a two-year period, as well as an overview of the relevant embryology and different clinical presentations of nasopharyngeal bursitis. For 2008-2009, six patients were diagnos...

This study looked at 128 nasopharyngeal aspirates (NPA) and 162 throat swabs (TS) tested with the Diagenode multiplex assay on the BD Max system versus our in-house Bordetella pertussis PCR. Sensitivity and specificity were 97.3% and 100% for NPA and 88.3% and 98% for TS, respectively. Of positive NPA, 42.1% were coinfected with respiratory viruses.

The invasion and metastasis processes involved in nasopharyngeal carcinoma (NPC) remain enigmatic. Transient receptor potential channel-related protein 1 (TRPC1) is a cation channel involved in diverse cellular functions by precisely controlling Ca2+. The role of this unique TRPC member in nasopharyngeal malignancies has not yet been delineated. H...