Most RNA molecules collapse rapidly and reach the native state through a pathway that contains numerous traps and unproductive intermediates. The D135 group II intron ribozyme is unusual in that it can fold slowly and directly to the native state, despite its large size and structural complexity. Here we use hydroxyl radical footprinting and native gel analysis to monitor the timescale of terti...

Research has shown that avian malaria plays an important role in limiting the distribution and population sizes of many Hawaiian birds, and that projected climate change is likely to eliminate most disease-free habitat in Hawai’i in the next century. I used a modeling approach, parameterized with demographic data from the literature and the field, to examine alternate management scenarios for t...

What is the process by which our brains recognize higher-order visual objects, like faces, words and foreign scripts? How does perception change with experience, and what are the implications for human behavior? We are interested in exploring the extent to which face processing and word processing are mediated by different or same hemispheric mechanisms, and the extent to which experience with ...

Here we investigated how the language in which a person addresses us, native or foreign, influences subsequent face recognition. In an old/new paradigm, we explored the behavioral and electrophysiological activity associated with face recognition memory. Participants were first presented with faces accompanied by voices speaking either in their native (NL) or foreign language (FL). Faces were t...

Speech sounds are not always perceived in accordance with their acoustic-phonetic content. For example, an early and automatic process of perceptual repair, which ensures conformity of speech inputs to the listener's native language phonology, applies to individual input segments that do not exist in the native inventory or to sound sequences that are illicit according to the native phonotactic...

The policy-based management paradigm in a flexible manner governs the system behavior. For Cloud-native applications, additionally, it simplifies compliance with CI/CD objectives. Hence, velocity of changes requirements made at runtime does not influence implementation. Continuously adjustments are integrated into on fly. This paper evaluates rule-based approach to representing policies context...

one of the modern paradigms to develop an application is object oriented analysis and design. in this paradigm, there are several objects and each object plays some specific roles in applications. in an application, we must distinguish between procedural semantics and declarative semantics for their implementation in a specific programming language. for the procedural semantics, we can write a ...

the term paradigm hase penetrated in the web of many fields form natural to social sciences. therefore, for each researcher, understanding it's concept and dimensions is necessary. it is become to a common term in philsophy of science. there are many definitions of paradigm, but we can define it as: a set of believes and basic assumptions that are reflected in the ontology, epistemology an...

The United Nations Decade on Ecosystem Restoration aims to prevent, halt, and reverse the degradation of ecosystems every continent. Disturbances stemming from anthropogenic or natural causes make plant community restoration challenging. introduction fast-growing weeds that generate high biomass produce copious seed is most threatening communities. A paradigm shift in ecosystem needed emphasize...

Energy landscape theories have provided a common ground for understanding the protein folding problem, which once seemed to be overwhelmingly complicated. At the same time, the native state was found to be an ensemble of interconverting states with frustration playing a more important role compared to the folding problem. The landscape of the folded protein - the native landscape - is glassier ...