Microbes may quickly acquire resistance to the antibiotics used, since antibiotic agents are now extensively applied in treatment of infectious diseases in clinic. Novel antimicrobial agents are therefore urgently needed to overcome the resistance issue. Up to date, great efforts have been made in identifying the new antimicrobial agents from natural resources as alternative approach. Peptide t...

Marine bacteria were isolated from seawater was collected from different coastal areas of the Tamilnadu Sea. The antimicrobial activities of these bacteria were investigated. Ethyl acetate extracts of marine bacterial fermentation were screened for antimicrobial activities using the method of agar diffusion. The results showed that 25 strains of the isolates have antimicrobial activity. The pro...

The effect of C-terminal amidation on the antimicrobial and hemolytic activities of antimicrobial peptides was studied using three cationic peptides which form amphiphilic α-helices when bound to membranes. The natural antimicrobial peptide PGLa, the designermade antibiotic MSI-103, and the cell-penetrating “model amphipathic peptide” (MAP) are all amidated in their original forms, and their bi...

The present work was designed to evaluate the in vitro lipid peroxidation inhibitory and antimicrobial activities of the methanol extract of Phyllanthus niruri (MEPN) (Family:   Euphorbiaceae) .   Lipid peroxidation was measured by the optical density of the prepared solutions (10-320 µg/ml) and then the percent inhibition was calculated. Ascorbate/FeSO 4 -induced p...

Domesticated animals have a large variety of antimicrobial peptides that serve as natural innate barriers limiting microbial infection or, in some instances, act as an integral component in response to inflammation or microbial infection. These peptides differ in size, composition, mechanisms of activity and range of antimicrobial specificities. They are expressed in many tissues, polymorphonuc...

Most antimicrobial peptides (AMPs) are cationic molecules with a high content of basic amino acids. They often undergo C-terminal amidation that may be related to their antimicrobial activity. Here we describe a mass spectromety (MS)-based approach for identifying novel AMPs. MS is used to profile peptides secreted by endocrine cells. Peptide sequences characteristic of AMPs are selected to tes...

This study screened the available evidence for the in vitro antimicrobial efficacy of propolis, a natural herbal resin bee product, against a selection of three bacterial species of relevance to oral diseases. For this purpose, papers dealing with laboratory studies assessing minimum inhibitory concentration (MIC), minimum bactericidal concentrations (MBC) or the agar diffusion method to analyz...