نتایج جستجو برای: natural regulatory t cells

تعداد نتایج: 2435484  

Journal: :Haematologica 2010
Rosa Bacchetta Silvia Gregori Giorgia Serafini Claudia Sartirana Ute Schulz Elisabetta Zino Stefan Tomiuk Uwe Jansen Maurilio Ponzoni Carlo Terenzio Paties Katharina Fleischhauer Maria Grazia Roncarolo

BACKGROUND CD4(+) regulatory T cells are a specialized subset of T cells that actively control immune responses. Several experimental protocols have been used to expand natural regulatory T cells and to generate adaptive type 1 regulatory T cells for regulatory T-cell-based therapies. DESIGN AND METHODS The ability of exogenous recombinant human interleukin-10 to induce alloantigen-specific a...

Journal: :Clinical & Experimental Immunology 2009

Journal: :Blood 2008
Anne S De Groot Leonard Moise Julie A McMurry Erik Wambre Laurence Van Overtvelt Philippe Moingeon David W Scott William Martin

We have identified at least 2 highly promiscuous major histocompatibility complex class II T-cell epitopes in the Fc fragment of IgG that are capable of specifically activating CD4(+)CD25(Hi)FoxP3(+) natural regulatory T cells (nT(Regs)). Coincubation of these regulatory T-cell epitopes or "Tregitopes" and antigens with peripheral blood mononuclear cells led to a suppression of effector cytokin...

Journal: :Journal of immunology 2003
Pascal Feunou Lionel Poulin Claude Habran Alain Le Moine Michel Goldman Michel Y Braun

The repeated injection of low doses of bacterial superantigens (SAg) is known to induce specific T cell unresponsiveness. We show in this study that the spleen of BALB/c mice receiving chronically, staphylococcal enterotoxin B (SEB) contains SEB-specific CD4(+) TCRBV8(+) T cells exerting an immune regulatory function on SEB-specific primary T cell responses. Suppression affects IL-2 and IFN-gam...

Journal: :Journal of Investigative Dermatology 2012

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