Mesenchymal stem cell (MSC) transplantation alone may be insufficient for treatment of liver fibrosis because of complicated histopathological changes in the liver. Given that miR-122 plays an essential role in liver fibrosis by negatively regulating the proliferation and transactivation of hepatic stellate cells (HSCs), this study investigated whether miR-122 modification can improve the thera...

BACKGROUND In the present study we retrospectively evaluated the results of outpatients who had an HPV analysis, and present objective evidence for the administration of preventive inoculation in our area. MATERIAL AND METHODS We retrospectively reviewed 532 outpatients who visited a single center between 2012 and 2016 and had an HPV infection analysis. The criteria for inclusion of patients wi...

By combining expressions A.1 and A.2 it becomes clear that the variance ratio is equal to 1 when the sum of population covariances is zero (population dynamics are independent), whereas values greater (less) than 1 indicate positive (negative) covariances and thus synchronous (compensatory) dynamics amongst populations. The variance ratio reflects the cumulative population dynamics rather than ...

Parathyroid carcinoma is an uncommon cause of PTHdependent hypercalcemia. The collective published experience with this rare neoplasm has provided a distinctive clinical profile that differs in a number of respects from that of benign primary hyperparathyroidism (1–3). The distinguishing features of parathyroid carcinoma assume even greater prominence when viewed within the current context of p...

Hepatitis C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-122. A recent clinical trial reported that transient inhibition of miR-122 reduced viral titres in HCV-infected patients. Here we set out to better understand how miR-122 inhibition influences HCV replication over time. Unexpectedly, we observed the emergence of an HCV variant that is resistant to miR-122...

Follicular dendritic cell sarcoma is an extremely rare malignant neoplasm arising from follicular dendritic cells, and this was fi rst described in 1986 by Monda et al. (1). About 60% of the cases occur in lymph nodes such as the cervical, axillary and mediastinal lymph nodes, while a wide variety of extranodal sites may also be affected, including the tonsil, spleen, liver, gastrointestinal tr...

PIERRE BELON, naturalist and traveler of the 16th century, known for his publications in field botany zoology, above all account voyage to Levant (1546-1549), is also author Cronique, unpublished sixteenth century. This polemical work describes events beginning French Wars Religion that Belon witnessed. It consists a speech addressed King Charles IX two accounts sieges: Moulins imposed by Hugue...