The e+ecollider DAΦNE, a 1.02 GeV c.m. Φ-factory, has reached a peak luminosity of about 1.4x10 cm s and a peak integrated luminosity in one day of about 8.6 pb. With the current rates the physics program of the three main experiments DEAR, FINUDA and KLOE will be completed by the end of 2007. In this paper we describe in detail the steps which have led to the luminosity improvement and the opt...

Total number concentrations, number concentrations of ultra"ne (0.01}0.1 m) and accumulation (0.1}0.5 m) particles, as well as mass concentration of PM particles and blackness of PM "lters, which is related to Black Smoke were simultaneously monitored in three European cities during the winter period for three and a half months. The purpose of the study was to describe the di!erences in concent...

Experimental findings suggest a pronounced concentration gradient of norepinephrine (NE) between the intravascular and interstitial compartments of the heart, compatible with an active neuronal reuptake (U1) and/or an endothelial barrier. Using the microdialysis technique in eight anesthetized pigs, we investigated this NE gradient, both under baseline conditions and during increments in either...

OBJECTIVE Vasopressor agents are often prescribed in septic shock. However, their effects remain controversial. We conducted a systematic review and Bayesian network meta-analysis to compare the effects among different types of vasopressor agents. DATA SOURCES We searched for relevant studies in PubMed, Embase, and the Cochrane Library databases from database inception until December 2014. ...

We tested the hypothesis that pressor infusions of angiotensin II (AII) could stimulate the sympathetic nervous system as reflected by norepinephrine (NE) spillover in humans. AII was infused at 5 ng/kg/min in six healthy volunteers, with vehicle and phenylephrine infusions as controls, on 3 separate days. Heart rate, mean arterial pressure, plasma NE, NE clearance, and NE spillover were assess...

Chromosome dynamics during meiotic prophase I are associated with a series of major events such as chromosomal reorganization and condensation, pairing/synapsis and recombination of the homologs, and chromosome movements at the nuclear envelope (NE). The NE is the barrier separating the nucleus from the cytoplasm and thus plays a central role in NE-associated chromosomal movements during meiosi...

Intrauterine growth-restricted (IUGR) fetuses experience prolonged hypoxemia, hypoglycemia, and elevated norepinephrine (NE) concentrations, resulting in hypoinsulinemia and β-cell dysfunction. Previously, we showed that acute adrenergic blockade revealed enhanced insulin secretion responsiveness in the IUGR fetus. To determine whether chronic exposure to NE alone enhances β-cell responsiveness...

Underlying the nuclear envelope (NE) of most eukaryotic cells is the nuclear lamina, a meshwork consisting largely of coiled-coil nuclear intermediate filament proteins that play a critical role in nuclear organization and gene expression, and are vital for the structural stability of the NE/nucleus. By confocal microscopy and micromanipulation of the NE in living cells and isolated nuclei, we ...