1 Centre for Global Health, Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom, 2 Mycotic Diseases Branch, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America, 3 Medecins Sans Frontières Access Campaign, Médecins Sans Frontières, Geneva, Switzerland, 4 National Institute for Communicable Diseases (Centre for Healthc...

Needle-based procedures, such as biopsy, thermal ablation, brachytherapy, and drug delivery, provide a minimally invasive means for diagnosis or treatment. The success of the procedure relies on the needle reaching the physician’s desired target (typically identified on a medical image) accurately. However, due to tissue deformation and the accuracy limits of human hand–eye coordination, the ne...

The diagnostic and clinical usefulness of a powered bone marrow biopsy device (OnControl()) versus a standard manual device (TRAP Hospital System) was studied. Primary endpoints were biopsy quality and patient pain during the procedure. Fifty patients underwent a total of 60 procedures by three expert operators in a randomised stratified fashion. Baseline demographic and clinical parameters wer...

The present work analyses climatological variations of Convective Available Potential Energy (CAPE) and Inhibition (CIN) over the eastern India (Odisha, West Bengal Jharkhand) during pre-monsoon season, where thunderstorms are frequent disastrous. utilises European Centre for Medium-Range Weather Forecast (ECMWF) reanalysis data: ERA-5 1987-2016, supplemented with information about thunderstorm...

We present a newly developed macromolecular ion accelerator mass spectrometer that combines a dual-ion-trap device and a macromolecular ion accelerator (MIA) to achieve the capability of analyzing samples with a mixture of large biomolecules. MIA greatly increases detection efficiency. The dual ion trap includes a quadrupole ion trap (QIT) and a linear ion trap (LIT) in tandem. The dual ion tra...

Umami taste perception is mediated by the heterodimeric G-protein coupled receptors (GPCRs), formed by the assembly of T1R1 and T1R3 subunits. T1R1 and T1R3 subunits are class C GPCRs whose members share common structural homologies including a long N-terminal domain (NTD) linked to a seven transmembrane domain by a short cysteine-rich region. The NTD of the T1R1 subunit contains the primary bi...

Objective: Neural tube defect (NTD) incidence could be effectively reduced by folic acid supplementation before and during pregnancy. We studied single nucleotide polymorphisms (SNPs) involved in folate metabolism to explore genetic susceptibility to NTD. We studied the association between 12 SNPs involved in 11 folate metabolism genes and NTDs. Methods: We enrolled 76 children with NTD and 188...

Background: CaBP7 is an EF-hand-containing transmembrane protein that inhibits PI4KIII activity. Results: PI4KIII interacts with CaBP7 NTD, which exhibits an expansive hydrophobic pocket. Conclusion: The structure of CaBP7 NTD is similar to that of CaM NTD but has a more expansive hydrophobic pocket containing fewer methionine residues. Significance: Regulation of PI4P synthesis is essential fo...