Abstract More than 25 years ago, Donald Stokes argued that we must move beyond the false dichotomy of basic or applied research and suggested when considering a program scientific it is important to ask whether (i) work motivated by use (ii) if there search for fundamental understanding. Giving yes/no answers these questions allows us characterize more fully, replacing “or” “basic applied” rich...

Signal regulatory proteins of the alpha subtype (SIRPalpha) are ubiquitous molecules of the immunoglobulin superfamily that negatively regulate protein tyrosine kinase receptor-dependent cell proliferation. Their intracytoplasmic domain contains four motifs that resemble immunoreceptor tyrosine-based inhibition motifs (ITIMs) and that, when tyrosyl-phosphorylated, recruit cytoplasmic SH2 domain...

Septins constitute a family of GTP-binding proteins that are involved in a variety of biological processes. Several isoforms have been implicated in disease, but the molecular mechanisms underlying pathogenesis are poorly understood. Here, we show that depletion of SEPT9 decreases surface levels of epidermal growth factor receptors (EGFRs) by enhancing receptor degradation. We identify a consen...