Neglected tropical diseases affect more than one billion people worldwide. The populations most impacted by such diseases are typically the most resource-limited. Mathematical modeling of disease transmission and cost-effectiveness analyses can play a central role in maximizing the utility of limited resources for neglected tropical diseases. We review the contributions that mathematical modeli...

July 2007 | Volume 4 | Issue 7 | e241 The neglected tropical diseases (NTDs) are a group of chronic infections that are often considered together because they primarily affect one billion of the world’s poorest people and attract little attention from the global medical community [1]. The United Nations Millennium Development Goals (http:⁄⁄www.un.org/ millenniumgoals/) call for increased fundin...

BACKGROUND In 1975-99, only 1·1% of new therapeutic products had been developed for neglected diseases. Since then, several public and private initiatives have attempted to mitigate this imbalance. We analysed the research and development pipeline of drugs and vaccines for neglected diseases from 2000 to 2011. METHODS We searched databases of drug regulatory authorities, WHO, and clinical tri...

Development Progress is an ODI project that aims to measure, understand and communicate where and how progress has been made in development. ODI is the UK's leading independent think tank on international development and humanitarian issues. Further ODI materials are available at odi.org.uk • Neglected tropical diseases (NTDs) have a direct impact on the achievement of the Millennium Developmen...

BACKGROUND Recently, a number of Global Health Initiatives (GHI) have been created to address single disease issues in low-income countries, such as poliomyelitis, trachoma, neonatal tetanus, etc.. Empirical evidence on the effects of such GHIs on local health systems remains scarce. This paper explores positive and negative effects of the Integrated Neglected Tropical Disease (NTD) Control Ini...

BACKGROUND Neglected Tropical Diseases are a set of communicable diseases that affect the population so low socioeconomic status, particularly 1.4 billion people who are living below the poverty level. This study has investigated the magnitude and mortality time trends for these diseases in the state of Sergipe, Northeast Region of Brazil. METHODS We conducted an ecological study of time seri...

Schistosomiasis and trichuriasis are two of the most common neglected tropical diseases (NTD) that affect almost a billion people worldwide. There is only a limited number of effective drugs to combat these NTD. Medicinal plants are a viable source of parasiticides. In this study, we have investigated six of the 19 phytochemicals isolated from two Bhutanese medicinal plants, Corydalis crispa an...

Schistosomiasis, a neglected tropical disease of poverty ranks second among the most widespread parasitic disease in various nations in sub-Saharan Africa. Neglected tropical diseases are causes of about 534,000 deaths annually in sub-Saharan Africa and an estimated 57 million disability-adjusted life-years are lost annually due to the neglected tropical diseases. The neglected tropical disease...