Current strategies for the treatment of Alzheimer's disease (AD) involve tackling the formation or clearance of the amyloid-beta peptide (Aβ) and/or hyper-phosphorylated tau, or the support and stabilization of the remaining neuronal networks. However, as we gain a clearer idea of the large number of molecular mechanisms at work in this disease, it is becoming clearer that the treatment of AD s...

Simplified procedures are commonly employed to estimate seismic displacements of earth and waste fills. The landmark work of Makdisi and Seed (1978) has been widely adopted in practice. Although this work is widely used, it has a number of significant limitations such as decoupling the sliding block analysis from the seismic response analysis, use of a limited number of recorded earthquake moti...

Lake Oroville is a large artificial lake created by the construction of a 235-mhigh earth dam on the Feather River, California, near the city of Oroville. Its storage capacity is about 4.4 × 109 m 3, and its maximum depth is about 200 m. There was no significant increase in seismic activity in the lake region following impoundment of the dam late in 1967 until the occurrence of many small seism...

A field experiment was conducted during 2001-2003 to evaluate the effect of water stress on the yield and yield components of four rice cultivars commonly grown in Mazandaran province, Iran. In northern Iran irrigated lowland rice usually experiences water deficit during the growing season include of land preparation time, planting, tillering stage, flowering and grain filing period. Recently d...

Cosmologically motivated theories that explain small acceleration rate of the Universe via modification of gravity at very large, horizon or super-horizon distances, can be tested by precision gravitational measurements at much shorter scales, such as the Earth-Moon distance. Contrary to the naive expectation the predicted corrections to the Einsteinian metric near gravitating sources are so si...

The Coralville Reservoir’s capacity is shrinking. Since the dam that created the Reservoir was completed in 1958, approximately 11 percent of the storage basin’s capacity has been lost to silt, said Ron Fournier, a spokesman for the U.S. Army Corps of Engineers. “Construction projects, farming — pretty much any time earth is moved, rain will wash away dirt,” he said. “Then streams fill up with ...

The Red Rock Hydroelectric Project converted the existing Dam near Pella, Iowa, from a non-powered dam into multi-purpose dam. flood control was constructed by U.S. Army Corps of Engineers (USACE) in 1960s on Des Moines River Iowa. hydroelectric project developed Western Minnesota Municipal Power Agency and generates up to 55 MW with an average annual energy output 178 gigawatt-hours. new intak...

introduction the lulak abad iron occurrence is located in the northwestern part of the central iran, 55 km west of zanjan. mineralization at the lulak abad area was originally identified by zamin gostar company (2007), during a geophysical exploration. the present paper provides an overview of the geological framework, the mineralization characteristics, and the results of a geochemical study o...

In a Perspective accompanying Abad-Franch and colleagues, Lorenz von Seidlein, Alexander Kekulé, and Daniel Strickman discuss the importance of developing effective strategies to minimize mosquito-borne transmission of human diseases.