Preand probiotics (synbiotics) are suggested to have beneficial effects on human health. This study describes effects of an amino acid based formula (AAF) with synbiotics in infants with cow’s milk allergy (CMA). In a prospective, randomized, double-blind controlled study, full term infants with diagnosed IgE and/or non-IgE mediated CMA received a commercially available AAF (NEO; n=56) or an AA...

BACKGROUND Gene-poor, degenerate Y chromosomes have evolved repeatedly from ordinary autosomes, but little is known about the processes that silence most genes on an evolving Y. RESULTS Here, I quantify relative expression levels of 58 gene pairs on the recently formed neo-sex chromosomes of Drosophila miranda, in order to test competing models of gene inactivation on its newly evolving Y chr...

We now realize, from the case of 2008 TC3’s discovery and subsequent impact in Sudan, that it is much more likely that a Near Earth Object (NEO) large enough to cause damage on the ground will be found (by the current Spaceguard Survey telescopes) on its "death plunge," providing a couple weeks of warning, than that a dangerous NEO will be found years or decades before impact. We also understan...

Necrotizing external otitis (NEO) is an invasive infectious disease involving the cartilaginous and/or bony external auditory canal (EAC) that particularly affects immunocompromised patients.1 Patients usually present with unrelenting otalgia that is disproportionate to the clinical signs and purulent otorrhea. The diagnosis of NEO is based on a combination of clinical, laboratory, and imaging ...

This study evaluates the validity of derived measures of the psychopathic personality traits of Fearless Dominance and Impulsive Antisociality from the NEO Personality Inventory-Revised (NEO-PI-R; Costa & McCrae, 1992) using data from the Collaborative Longitudinal Personality Disorders Study (baseline N = 733). These 3 issues were examined: (a) the stability of the measures over a 10-year inte...

The goal was to examine the nature of social anhedonia using two validated measures and study their relationship to scores on the NEO-Five Factor Inventory (NEO-FFI). Nearly 1,900 college-aged participants completed the Chapman Revised Social Anhedonia Scale (RSAS), Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS), and the NEO-FFI. Although both the RSAS and ACIPS were associa...

The neo (neomycin phosphotransferase) gene is widely used as a selection marker in the production of genetically engineered animals and plants. Recent attention has been focused on safety concerns regarding neo transgene expression. In this study, neo transgenic and non-transgenic piglets were randomly assigned into Group A and Group B to evaluate effects of neo transgene by studying changes in...

Recombinant adeno-associated virus 2 (AAV) virions were constructed containing a gene for resistance to neomycin (neoR), under the control of either the herpesvirus thymidine kinase (TK) gene promoter (vTK-Neo), or the human parvovirus B19 p6 promoter (vB19-Neo), as well as those containing an upstream erythroid cell-specific enhancer (HS-2) from the locus control region of the human beta-globi...

Sex chromosomes originated from autosomes but have evolved a highly specialized chromatin structure. Drosophila Y chromosomes are composed entirely of silent heterochromatin, while male X chromosomes have highly accessible chromatin and are hypertranscribed as a result of dosage compensation. Here, we dissect the molecular mechanisms and functional pressures driving heterochromatin formation an...

This paper discusses Michael Dummett’s criticism of the Neo-Fregean conception of the context principle. I will present four arguments by Dummett that purport to show that the context principle is incompatible with platonism. I discuss and ultimately reject each argument. I will close this paper by identifying what I take to be a deeprooted tension in the Neo-Fregean project which might have mo...