There is a significant potential benefit for induction chemotherapy in the management of non-small cell lung cancer (NSCLC). The real extent of such benefit is difficult to assess on the basis of avail¬ able data owing to the intrinsic limitations of phase II studies. In fact, in most studies on neoadju¬ vant chemotherapy, the aim of the treatment (local control vs systemic effect) is often unc...

Although neoadjuvant chemotherapy is a standard therapy for treating locally advanced breast cancer, it usually can’t achieve expected results owing to patients’ different chemotherapeutic sensitivity. At present, some certain progress have made in treating breast cancer by adjuvant chemotherapy combined with Traditional Chinese Medicine (TCM). Being effective for suppressing tumor growth, impr...

BACKGROUND Squamous cell carcinoma of the oral tongue (SCCOT) in the young population has emerged as a growing worldwide health problem. Standard therapies, consisting primarily of surgery with possible adjuvant radiotherapy, have resulted in only modest improvements in survival in recent decades, whereas the treatments for SCCOT continue to impair oral function. With the increased use and impr...

PURPOSE Little information exists about the possible influence of serum HER2/neu on response to chemotherapy. We propose that the assessment of serum HER2/neu in a pretreatment serum sample may be useful in predicting response to neoadjuvant chemotherapy. METHODS All breast cancer patients were tested by immunohistochemical stain and fluorescent in situ hybridization for HER2/neu before treat...

OBJECTIVE To compare the efficacy of neoadjuvant chemotherapy with paclitaxel plus platinum followed by radical hysterectomy with radical surgery alone in patients with stage IB2-IIA bulky cervical cancer. METHODS From November 1999 to September 2007, stage IB2-IIA cervical cancers with tumor diameter >4 cm, as measured by MRI, were managed with two cycles of preoperative paclitaxel and plati...

The use of neoadjuvant chemotherapy has become more prevalent in the treatment of breast cancer patients. The finding of a pathologic complete response to neoadjuvant chemotherapy (no evidence of residual invasive cancer in the breast and lymph nodes at the time of surgical resection) has been shown to correlate with improved survival. The current version of the American Joint Committee on Canc...

Optimal management of clinical stage IIIA (N2) non-small cell lung cancer (NSCLC) is controversial. This study is a systematic review and meta-analysis of published randomized control trials of multimodality management strategies for NSCLC. We conducted a comprehensive literature search of the Pubmed, Embase, Medline, and CENTRAL databases for relevant studies comparing patients with stage IIIA...

AMA Benek S, Zengin M. Clinical role of CD274 (PD-L1) and CD3+ lymphocytes in predicting high risk advanced colorectal cancer patients receiving neoadjuvant chemotherapy. Polish Journal Pathology. 2023. doi:10.5114/pjp.2023.129520. APA Benek, S., & Zengin, (2023). https://doi.org/10.5114/pjp.2023.129520 Chicago Suat, Mehmet Zengin. "Clinical chemotherapy". Harvard MLA Suat et al. chemotherapy."...

Little information is available on the evolvement of chemotherapeutic regimens administered to Chinese females with breast cancer. We retrospectively analyzed demographic, pathological and chemotherapeutic data of 4211 breast cancer patients, who were randomly selected from representative hospitals of 7 traditional areas in China between 1999 and 2008. A total of 3271 cases (77.7%) received adj...

Neoadjuvant radio chemotherapy and immediate reconstruction for breast cancer are still under debate. But there are recent abstracts and articles which show that neoadjuvant radio chemotherapy is feasible and could improve the clinical outcome of breast cancer patients. The aim of this review is to present the authors' techniques and approaches with regard to neoadjuvant radiation of breast can...