background: improving the neonatal health and reducing the neonatal mortality rate is valuable for not only health reasons, but social, psychological and economic reasons. it has advantages not just for the neonatal period of life but for the whole life. unfortunately in iran, in spite of efforts, there has been little success in decreasing the neonatal mortality rate. since investigating the c...

background: neonatal cholestasis is an important infant’s diseases of liver and biliary, they are wide range of situation including; idiopathic neonatal hepatitis, extrahepatic biliary tract atresia, choledochal cysts and infectious diseases. lack of early diagnosis of the disease can be followed by irreparably complications. the aim of this study was determination the histopathological causes ...

HIV-1 integrase is an essential enzyme for the replication cycle, and currently, inhibitors are in first line of treatment many guidelines. Despite discovery new inhibitors, including a class molecules with different mechanisms action, resistance still relevant problem, adding options to therapeutic arsenal fight viral Sisyphean task. Because difficulty cost vitro screenings, machine learning-d...

Molecular docking is emerging as a frequently applied structure-based virtual technique in the drug design processes. The method could significantly reduce time required for development of novel and effective molecules compared to high-throughput screening. However, major drawback simulations high number false-positive ligands top-ranked solutions. Thus, this work focuses on optimization geneti...