The blood-brain barrier (BBB) restricts the entry of circulating drugs and xenobiotics into the brain, and thus its permeability to substances is a critical factor that determines their central effects. The infant brain is vulnerable to neurotoxic substances partly due to the immature BBB. The employment of in vitro BBB models to evaluate permeability of compounds provides higher throughput tha...

The liver plays a major role in the regulation of glucose homoeostasis. Evidence from liver-specific insulin receptor knockout mice (LIRKO) suggested that insulin's direct and indirect effects on glucose utilization by the liver both require the presence of hepatic insulin receptors (IR). To address this issue, we have generated immortalized neonatal hepatocytes bearing (HIR LoxP) or not (HIR K...

OBJECTIVES To determine the number and characteristics of inter-hospital transfers of newborn infants in London and the South East of England. DESIGN Prospective census of neonatal transfers over a three month period. SETTING Transfers between the 53 hospitals that provide care for newborn infants within the former Thames regions. DATA SOURCES Census returns from participating neonatal un...

This study explored the feasibility of high-resolution Mn-enhanced MRI (MEMRI) and diffusion tensor imaging (DTI) for in vivo assessments of the development and reorganization of retinal and visual callosal pathways in normal neonatal rodent brains and after early postnatal visual impairments. Using MEMRI, intravitreal Mn injection into one eye resulted in maximal T1-weighted hyperintensity in ...

sepsis is the most common cause of neonatal mortality. as per national neonatal-perinatal database (nnpd), 2002-2003, the incidence of neonatal sepsis in india was 30 per 1000 live births. signs and symptoms of sepsis are nonspecific; therefore empirical antimicrobial therapy is promptly initiated after obtaining appropriate cultures. the early manifestations of neonatal sepsis are vague and il...

background: neonatal infections are one of the major causes of death in iran. since identifying the risk factors, types, site, bacterial causes, and case fatality rate of an infection can be effective in selecting preventive and therapeutic methods, and appropriate supportive measures, this study aimed to investigate the aforementioned factors in the neonatal intensive care unit (nicu) of ghaem...