BACKGROUND Multiple myeloma (MM) is a malignant neoplasm of plasma cells that accumulate in the bone marrow. Myeloma is characterized by skeletal destruction, renal failure, hypercalcemia, and anemia. Currently, there is no cure, though recent understanding of the bone marrow microenvironment and the cytogenetics involved in MM are leading to improved and individualized treatment strategies, le...

The 2011 American Urological Association (AUA) annual meeting took place in Washington, DC, USA, on May 14-19. It is the largest gathering of urologists in the world, providing unparalleled access to groundbreaking research, new guidelines and the latest advances in urologic medicine. The opportunity to exchange knowledge among urologists on a worldwide level was provided by participation of mo...

The aim of this study was to examine the experience of cancer patients undergoing rehabilitation, to identify symptoms associated with rehabilitation from cancer, and to assess the need for rehabilitation services for cancer patients. Cancer patients (n = 402) at the Asan Medical Center (Seoul, Korea) were enrolled from June to September 2008. A chart review was used to collect demographic and ...

OBJECTIVES Although endoscopic ultrasound (EUS) staging of esophageal cancer is established in clinical practice, high-quality evidence about its impact on patient outcomes is not available. This study aims to determine the impact of EUS for esophageal cancer staging on patient management and survival. METHODS A systematic review was conducted using Medline, PreMedline, Embase, and The Cochra...

HYPOTHESIS Examination of 14 or more nodes is the optimal criterion to accurately stage node-negative colorectal cancer and predict outcome. DESIGN Case series. SETTING Three university-affiliated community medical centers. PATIENTS A total of 2149 individuals with apparently localized, invasive colorectal cancer examined between January 1, 1990, and December 31, 2002. INTERVENTION Stud...

BACKGROUND Tumor spatial heterogeneity is an important prognostic factor, which may be reflected in medical images METHODS Image texture analysis is an approach of quantifying heterogeneity that may not be appreciated by the naked eye. Different methods can be applied including statistical-, model-, and transform-based methods. RESULTS Early evidence suggests that texture analysis has the p...

BACKGROUND There are detailed reviews about different recruitment strategies, but not with regard to differences between recruitment of hospital-based versus office-based physicians. Within this study, the two different recruitment schemes are compared. Advantages and disadvantages of different ways of recruitment in registry-based studies are discussed. METHODS In a cross-sectional cancer-re...

OBJECTIVE The present study was conducted to identify possible dermoscopic patterns, associated with mitotic rate > 1/mm2, histological ulceration in melanoma and metastatic disease. METHODS For this retrospective data analysis all clinical and dermoscopic digital images of primary malignant melanomas between 2008 and 2013 documented at the Department of Dermatology Graz were included, using ...

SUMMARY The importance of good patient selection is becoming increasingly appreciated as a predictor of good outcomes following mastectomy and reconstruction. There are many variables that should be considered when making these decisions. Patient variables include breast characteristics, age, body habitus, comorbidities, and expectations. Oncological variables include tumor size, cancer stage, ...