BACKGROUND The aim of our study was to analyze spectral optical coherence tomography (SD-OCT) findings in a patient with clinical signs of sialidosis. CASE REPORT Fluorescein angiography and spectral optical coherence tomography was performed in a 37-year-old woman using a SD-OCT device with axial resolution of 6 µm. Enzyme assay followed. The patient was diagnosed with type I sialidosis by e...

Wedge shaped defects of the retinal nerve fiber layer (RNFL) may occur in glaucoma. Currently, automatic detection of wedge shaped defects in Scanning Laser Polarimetry images of the retinal nerve fiber layer is unavailable; an automatic classification is currently based only on global parameters, thereby ignoring important local information. Our method works by a modified dynamic programming t...

The organization of the retinal nerve fiber layer of the cynomolgus monkey was studied by electron microscopy. Nerve fiber size spectra were obtained from measurements of every fiber in enlarged montages of selected bundles. Variation in spectra among nasal, arcuate, and papillomacular bundles was examined, and variation of spectra of a given bundle as it crossed the retina was determined. Amon...

PURPOSE Losses of retinal ganglion cells (RGCs) in glaucoma are the cause of visual field defects and thinning of the retinal nerve fiber layer (RNFL), but methods of correlating these events have not been developed. The present study was conducted to investigate the relationship between standard automated perimetry (SAP) measures of RGCs and optical coherence tomography (OCT) measures of the g...

The aim of this study was to determine the sensitivity of retinal areas involved in a localized retinal nerve fiber layer (RNFL) defect and to assess correlations between microperimetry and the standard full threshold central 30 deg visual field test. Twenty-five patients with focal RNFL defects, evaluated by means of Argon-blue scanning laser ophthalmoscopy (SLO), underwent an automated 30 deg...

BACKGROUND Headache is one of the most disturbing symptoms with common neurological signs. Variations in optic nerve perfusion quality or retinal microcirculation may end up in ganglion cell damage in patients with migraine. METHODS Sixty patients diagnosed with migraine and thirty normal individuals were evaluated in groups including migraine with aura, migraine without aura and controls. Re...

Recently developed optical techniques provide quantitative structural measurements of the retinal nerve fiber layer (RNFL). A complete interpretation of these measurements requires understanding of the optical properties of the RNFL. This paper gives a review of the polarization properties and relevant anatomy of the ocular tissues, followed by a thorough discussion of the optical properties of...

PURPOSE To investigate, using optical coherence tomography (OCT), whether retinal nerve fiber layer thickness (RNFLT) is affected in amblyopic eyes. METHODS Using OCT (Stratus OCT™ [Carl Zeiss, Dublin, CA]), the RNFLT was measured in 26 patients with persistent unilateral amblyopia and in 25 patients with recovered unilateral amblyopia. The RNFLT was compared between the affected and fellow e...

The organization of nerve fiber bundles, stained by microelectrode injection of horseradish peroxidase, was examined in the retina of the owl monkey. Fibers were traced across the retina in whole mounts and serial sections to evaluate their retinotopic order. Long nasal fibers showed little tendency to wander among bundles but were distributed randomly within the bundles near the disc. Long arc...

PURPOSE To determine whether the nerve fiber analyzer GDx with the new variable corneal compensation (VCC) device allows measurements of retinal nerve fiber layer parameters independent from birefringence changes of the cornea after photorefractive keratectomy (PRK). METHODS Retinal nerve fiber layers of 32 eyes in 32 myopic patients undergoing PRK were analyzed using the GDx-VCC. Photorefrac...