نتایج جستجو برای: neural circuitry

تعداد نتایج: 312343  

2017
Jonas Doerr Martin Karl Schwarz Dirk Wiedermann Anke Leinhaas Alina Jakobs Florian Schloen Inna Schwarz Michael Diedenhofen Nils Christian Braun Philipp Koch Daniel A. Peterson Ulrich Kubitscheck Mathias Hoehn Oliver Brüstle

While transplantation represents a key tool for assessing in vivo functionality of neural stem cells and their suitability for neural repair, little is known about the integration of grafted neurons into the host brain circuitry. Rabies virus-based retrograde tracing has developed into a powerful approach for visualizing synaptically connected neurons. Here, we combine this technique with light...

Journal: :The Journal of physiology 2015
Seungmoon Song Hartmut Geyer

KEY POINTS It is often assumed that central pattern generators, which generate rhythmic patterns without rhythmic inputs, play a key role in the spinal control of human locomotion. We propose a neural control model in which the spinal control generates muscle stimulations mainly through integrated reflex pathways with no central pattern generator. Using a physics-based neuromuscular human model...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2003
Kevin M Spencer Paul G Nestor Margaret A Niznikiewicz Dean F Salisbury Martha E Shenton Robert W McCarley

Schizophrenia has been conceptualized as a failure of cognitive integration, and abnormalities in neural circuitry (particularly inhibitory interneurons) have been proposed as a basis for this disorder. We used measures of phase locking and phase coherence in the scalp-recorded electroencephalogram to examine the synchronization of neural circuits in schizophrenia. Compared with matched control...

Journal: :The journals of gerontology. Series A, Biological sciences and medical sciences 1997
H T Blumenthal

The greater longevity of humans over other mammalian species is provided, in large part, by the complex neural circuitry of the brain. Assurance of the integrity of this circuitry is partly provided by its neural plasticity. The brain is also protected from adverse systemic phenomena by the blood-brain and blood-cerebrospinal fluid barriers. However, these barriers do not protect the brain from...

Journal: :Exercise and sport sciences reviews 2009
V Reggie Edgerton Roland R Roy

The lumbosacral spinal cord of mammals contains the neural circuitry capable of generating full weight-bearing locomotion of the hind limbs without any supraspinal input. One or more interventions, for example, pharmacological, epidural stimulation, and/or locomotor training, however, are necessary to gain access to and modulate the properties of this circuitry and to facilitate recovery of ful...

Journal: :Current Biology 2002
Marie Carlén Robert M. Cassidy Hjalmar Brismar Gregory A. Smith Lynn W. Enquist Jonas Frisén

Over the past decade, it has become clear that neural stem cells in the adult mammalian brain continuously generate new neurons, predominantly in the hippocampus and olfactory bulb. However, the central issue of whether these new neurons participate in functional synaptic circuitry has yet to be resolved. Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced ...

Journal: :Neuron 2013
Jun Takatoh Anders Nelson Xiang Zhou M. McLean Bolton Michael D. Ehlers Benjamin R. Arenkiel Richard Mooney Fan Wang

Rodents begin to use bilaterally coordinated, rhythmic sweeping of their vibrissae ("whisking") for environmental exploration around 2 weeks after birth. Whether (and how) the vibrissal control circuitry changes after birth is unknown, and the relevant premotor circuitry remains poorly characterized. Using a modified rabies virus transsynaptic tracing strategy, we labeled neurons synapsing dire...

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