نتایج جستجو برای: neuregulin 3
تعداد نتایج: 1812651 فیلتر نتایج به سال:
We describe the identification of Neuregulin-3 (NRG3), a novel protein that is structurally related to the neuregulins (NRG1). The NRG1/neuregulins are a diverse family of proteins that arise by alternative splicing from a single gene. These proteins play an important role in controlling the growth and differentiation of glial, epithelial, and muscle cells. The biological effects of NRG1 are me...
Neuregulin 3 (NRG3), a specific ligand for ErbB4 and a neuronal-enriched neurotrophin is implicated in the genetic predisposition to a broad spectrum of neurodevelopmental, neurocognitive and neuropsychiatric disorders, including Alzheimer's disease, autism and schizophrenia. Genetic studies in schizophrenia demonstrate that risk variants in NRG3 are associated with cognitive and psychotic symp...
BACKGROUND A deficit in impulse control is a prominent, heritable symptom in several psychiatric disorders, such as addiction, attention-deficit/hyperactivity disorder, and schizophrenia. Here, we aimed to identify genes regulating impulsivity, specifically of impulsive action, in mice. METHODS Using the widely used 5-choice serial reaction time task, we measured impulsive action in 1) a pane...
ed and automatically measured using CellProfiler cell image analysis software (http://www.cellprofiler.org, Broad Institute, Cambridge, MA, USA). 5-95% percentile box and whiskers plots were generated using median, quartiles, highest and lowest values. Statistical analysis The data in the graphs are presented as mean and the standard error of the mean (SEM). The data were analyzed by two-tailed...
Kuramochi, Yukio, Chee Chew Lim, Xinxin Guo, Wilson S. Colucci, Ronglih Liao, and Douglas B. Sawyer. Myocyte contractile activity modulates norepinephrine cytotoxicity and survival effects of neuregulin-1 . Am J Physiol Cell Physiol 286: C222–C229, 2004. First published October 1, 2003; 10.1152/ajpcell.00312.2003.—The purpose of this study is to test the hypothesis that mechanical and electrica...
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