Background. Earlier we found that plasma uric acid, urea and creatinine causes modulating effects on neuro-endocrine parameters, as well anxiety, but these are significantly different in men women of ages. The purpose this study is to analyze the relationships between bilirubin level some psycho-neuro-endocrine parameters same cohort. Materials Methods. object observation were almost healthy vo...

The efficient targeted delivery of nucleic acids in vivo provides some of the greatest challenges to the development of genetic therapies. We aim to develop nanocomplex formulations that achieve targeted transfection of neuroblastoma tumours that can be monitored simultaneously by MRI. Here, we have compared nanocomplexes comprising self-assembling mixtures of liposomes, plasmid DNA and one of ...

Multiple endocrine neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disorder characterised by the combination of endocrine tumours, such as parathyroid tumours, enteropancreatic tumours, anterior pituitary tumours, adrenal gland, and neuroendocrine carcinoid tumours, as well as non-endocrine expression, such as lipoma, facial angiofibroma, collagenoma, and ependymoma. 2 Primary hyp...

Carney complex (CNC) is an autosomal dominant multiple endocrine neoplasia and lentiginosis syndrome characterised by spotty skin pigmentation, cardiac, skin, and breast myxomas, and a variety of endocrine and other tumours. The disease is genetically heterogeneous; two loci have been mapped to chromosomes 17q22-24 (the CNC1 locus) and 2p16 (CNC2). Mutations in the PRKAR1A tumour suppressor gen...

Multiple endocrine neoplasia type 1 (MEN1, OMIM 131100) is an autosomal dominant disorder characterised by the combination of endocrine tumours, such as parathyroid tumours, enteropancreatic tumours, anterior pituitary tumours, adrenal gland, and neuroendocrine carcinoid tumours, as well as non-endocrine expression, such as lipoma, facial angiofibroma, collagenoma, and ependymoma. 2 Primary hyp...

Pituitary ademonas are benign tumours from the pituitary gland but may have an invasive and destructive growth pattern. There is little understanding of the growth and progression control of pituitary tumours. In the present study, we investigated the expression of vascular endothelial growth inhibitor (VEGI), a vascular endothelial growth and apoptosis regulator and VEGI receptor Death Recepto...

The sellar archnoidocele is a herniation of the subarachnoid space within sella turcica which often associated with variable degree flattening pituitary. Its clinical presentations range from an asymptomatic radiological finding to endocrine and neuro-ophthalmological manifestations. management depends on initial symptomatology requires long-term follow-up. We report here case young child follo...

Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and it has been demonstrated that SRIF and its analogs can inhibit hormone secretion and control the neoplastic bulk of several endocrine tumours. In vitro studies have contributed to the current knowledge of the mechanisms by which SRIF and its analogs may influence endocrine tumour proliferation, opening the w...

The medical treatment of neuroendocrine GEP tumours must be based on the growth properties of the tumour. Medical treatment includes chemotherapy, somatostatin analogues and alpha interferons. Chemotherapy has been particularly active in patients with high proliferating neuroendocrine tumours such as endocrine pancreatic tumours and lung carcinoids. Streptozotocin-based combinations including 5...