Bronwen Connor, Lecturer, Division of Pharmacology; Willeke MC van Roon-Mom, Assistant Research Fellow, Division of Anatomy with Radiology; Maurice A Curtis, PhD student, Division of Anatomy with Radiology; Michael Dragunow, Professor of Pharmacology, Division of Pharmacology; Richard LM Faull, Professor of Anatomy, Division of Anatomy with Radiology, Faculty of Medical and Health Sciences, Auc...

in Neurodegenerative Diseases contains an impressive overview of the role of mitochon-drial dysfunction as the primary effector of, or relevant mechanism leading to, neurodegeneration. In the 26 Mitochondria and Free Radicals in Neurodegenerative chapters featured in this book, the authors guide the Diseases reader from the basic concepts of mitochondrial function and free radical generation to...

The olfactory sensory network is a unique brain system. Among human sensory systems, only olfaction has a direct connection to the brain and no thalamic relay. In terms of tissue and cellular repair, the olfactory system is unusual, along with the hippocampal dentate gyrus, as an example of central nervous tissue in which neurogenesis persists. Additionally, olfaction has been shown to have an ...

Neurodegenerative diseases are responsible for agonizing symptoms that take their toll on the fragile human life. Aberrant protein processing and accumulation are considered to be the culprits of many classical neurodegenerative diseases such as Alzheimer’s disease, tauopathies, Parkinson’s disease, amyotrophic lateral sclerosis, hereditary spastic paraplegia and various polyglutamine diseases....

Neurodegenerative diseases are a large group of disabling disorders of the nervous system, characterized by the relative selective death of neuronal subtypes. In most cases, there is overwhelming evidence of impaired mitochondrial function as a causative factor in these diseases. More recently, evidence has emerged for impaired mitochondrial dynamics (shape, size, fission-fusion, distribution, ...

Noncoding RNAs are widely known for their various essential roles in the development of central nervous system. It involves neurogenesis, neural stem cells generation, maintenance and maturation, neurotransmission, neural network plasticity, formation of synapses, and even brain aging and DNA damage responses. In this review, we will discuss the biogenesis of microRNA, various functions of nonc...

1Neurophysiopathology of Pain Section, SMBNOS Department, Bari Aldo Moro University, Bari, Italy 2Center for Sensory-Motor Interaction, School of Medicine, Aalborg University, Aalborg, Denmark 3Department of Physical Therapy, Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel 4Section of Gerontology, Department of General Practice, University Medical Center Groningen, Groningen,...

Lead (Pb) pollution has been considered as a major threat for human health. Lead may be able to induce inflammatory cascades in various tissues. Allergic asthma and neurodegenerative diseases inflammatory diseases that the association between lead exposure and occurrence of these problems has been proven. The aim of present review is to summarize literature on the effects of lead exposure and o...

INTRODUCTION Olfactory impairment is a common occurrence in aging and may be an early signal of neurodegenerative diseases. Olfactory loss caused by aging and diseases affects both quality of life and personal safety. Aging, as well as viral infections, neurodegenerative diseases, head injuries, chronic sinusitis infections and nasal obstructions are the most common causes of olfactory disorder...