BACKGROUND Alzheimer's disease (AD) is a progressive neurodegenerative disease characterized by welldefined neuropathological brain changes including amyloid plaques, neurofibrillary tangles and the presence of chronic neuroinflammation. OBJECTIVE The brain penetrant BET bromodomain inhibitor JQ1 has been shown to regulate inflammation responses in vitro and in vivo, but its therapeutic poten...

BACKGROUND Burn scar pain is considered as neuropathic pain. The anti-inflammation and anti-neuroinflammation effects of adipose-derived stem cells (ASCs) were observed in several studies. We designed a study using a murine model involving the transplantation of autologous ASCs in rats subjected to burn injuries. The aim was to detect the anti-neuroinflammation effect of ASC transplantation and...

Chronic neuroinflammation is characteristic of neurodegenerative diseases and is present during very early stages, yet significant pathology and behavioral deficits do not manifest until advanced age. We investigated the consequences of experimentally-induced chronic neuroinflammation within the hippocampus and brainstem of young (4 mo) F-344 rats. Lipopolysaccharide (LPS) was infused continuou...

Research indicates that neuroinflammation plays a major role in postoperative cognitive dysfunction (POCD) in older patients. However, studies have mainly focused on hippocampal neuroinflammation and hippocampal-dependent learning and memory, which does not cover the whole spectrum of POCD. We hypothesized that regional differences in postoperative neuroinflammation in the brain may underlie va...

BACKGROUND AND PURPOSE In the elderly, cerebral ischemia (CI) occurs in the presence of high levels of amyloid. Neuroinflammation plays a critical role in the pathophysiology of Alzheimer's disease and CI. This study examined infarct size, neuroinflammation, and cognitive deficits over time in rat models of Alzheimer's disease and CI. METHODS beta-amyloid toxicity was modeled using bilateral ...

Alzheimer's disease (AD) is a neurodegenerative disease with major clinical hallmarks of memory loss, dementia, and cognitive impairment. Neuroinflammation is involved in the onset of several neurodegenerative disorders. Astrocyte is the most abundant type of glial cells in the central nervous system (CNS) and appears to be involved in the induction of neuroinflammation. Under stress and injury...

Citation: Li C, Zhang C, Zhou H, Feng Y, Tang F, Hoi MPM, He C, Ma D, Zhao C and Lee SMY (2018) Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polarization via CaMKKβ-Dependent AMPK Activation. Front. Mol. Neurosci. 11:98. doi: 10.3389/fnmol.2018.00098 Inhibitory Effects of Betulinic Acid on LPS-Induced Neuroinflammation Involve M2 Microglial Polariz...

∗Department of Neuroinflammation, Neuroimmunology Group, Institute of Neurology, Queen Square, London, WC1N 3BG, United Kingdom. Fax: +44 207 837 8553, E-mail: [email protected] †BioMérieux, R&D Department, Neurological Programs, Bat.07 Pieèce 112, Chemin de L’Orme, F–69290 Marcy L’Etoile, France ‡Department of Neuroinflammation, MRI Group, Institute of Neurology, Queen Square, London, WC...

Background: The relative contribution of COX2 and COX-1 to prostanoid formation under neuroinflammation is complex. Results: LPS induced COX-2 and mPGES1 but down-regulated COX-1 and TS in astroglia. These effects accounted for high production of PGE2. Conclusion: PGE2 after LPS results from the coordinated COX-2 up-regulation and COX-1 down-regulation in astrocytes. Significance: Changes in CO...

MicroRNAs (miRNAs) are small non-coding RNAs with the unique ability to degrade or block specific and regulate many cellular processes. Neuroinflammation plays pivotal role in occurrence development of multiple central nervous system (CNS) diseases. The miRNAs enhance restrict neuroinflammatory signaling pathways CNS diseases is an emerging important research area, including neurodegenerative d...