Understanding the role of neuromodulators socio-affective processing is important to ensure psychological wellbeing during older years. Here, we investigated link between blood serotonin levels and brain behavioral responses emotional information in healthy elderly. A priori regions interest (ROI) were selected due their emotion dense serotonergic innervation. Correlation analyses performed ROI...

Current treatments for autism spectrum disorders (ASD) are limited in efficacy and often associated with substantial side effects. These medications typically ameliorate problem behaviors ASD, but do not target core symptom domains. As a result, there is significant amount of research underway development novel experimental therapeutics. Endocannabinoids arachidonic acid-derived lipid neuromodu...

Puberty is a complex process that culminates in the acquisition of psychophysical maturity and reproductive capacity. This elaborate fascinating marks end childhood. Behind it lies complex, genetically mediated neuroendocrine mechanism through which gonads are activated thanks to fine balance between central inhibitory stimulating neuromodulators hormones with both peripheral action. The onset ...

Administration of cocaine and amphetamine increases cocaine- and amphetamine-regulated transcript (CART) expression in the rat striatum (Douglass et al., 1995). CART mRNA is highly expressed in different parts of the human and rat brain, including hippocampus (Douglass et al., 1995; Couceyro et al., 1997; Kuhar and Yoho, 1999; Hurd and Fagergren, 2000). The presence of CART peptide 55-102 immun...

The acquisition and expression of conditioned fear depends on prefrontal-amygdala circuits. Auditory fear conditioning increases the tone responses of lateral amygdala neurons, but the increase is transient, lasting only a few hundred milliseconds after tone onset. It was recently reported that that the prelimbic (PL) prefrontal cortex transforms transient lateral amygdala input into a sustaine...