To the Editor:—We read with interest article by Jonsson et al. suggesting that nondepolarizing neuromuscular blocking agents concentration-dependently inhibit human neuronal acetylcholine autoreceptors (nAChRs). The authors argue that the inhibition of the presynaptic 3 2 nAChR subtype plays an important role in tetanic and train-of-four fade seen during nondepolarizing neuromuscular blockade. ...

To the Editor:—We read with interest article by Jonsson et al. suggesting that nondepolarizing neuromuscular blocking agents concentration-dependently inhibit human neuronal acetylcholine autoreceptors (nAChRs). The authors argue that the inhibition of the presynaptic 3 2 nAChR subtype plays an important role in tetanic and train-of-four fade seen during nondepolarizing neuromuscular blockade. ...

BACKGROUND AND OBJECTIVES Lithium is widely used for the treatment of bipolar disorders and can interact with neuromuscular blockers. There is a controversy about the mechanisms by which it affects neuromuscular transmission and its interaction with neuromuscular blockers. The objective of this study was to evaluate, on the rat diaphragm, the effects of lithium on the muscular response and indi...