نتایج جستجو برای: neuronal aging
تعداد نتایج: 220967 فیلتر نتایج به سال:
introduction: although aging is the most important risk factor for alzheimer's disease (ad), there is evidence indicating that neuroinflammation may contribute to the development and progression of the disease. several studies indicated that minocycline may exert neuroprotective effects in rodent models of neurodegenerative diseases. nevertheless, there are also other studies implying that...
5 CHAPTER 1: RELATED LITERATURE 7 1.1. Aging 9 1.1.1. Aging as a regulated process 9 1.1.1.1. In search for a valuable approach to study stress resistance, proteostasis, and aging: Caenorhabditis elegans as a resourceful model 10 1.1.1.2. The insulin/IGF-1 signaling (IIS) pathway 12 1.1.1.3. Does the regulation of aging oppose cumulative damages? 15 1.2. The proteome and its challenges 15 1.2.1...
Physiological brain aging is characterized by synapses loss and neurodegeneration that slowly lead to an age-related decline of cognition. Neural/synaptic redundancy and plastic remodelling of brain networking, also due to mental and physical training, promotes maintenance of brain activity in healthy elderly subjects for everyday life and good social behaviour and intellectual capabilities. Ho...
A better understanding of the molecular effects of aging in the brain may help to reveal important aspects of organismal aging, as well as processes that lead to age-related brain dysfunction. In this study, we have examined differences in gene expression in the hypothalamus and cortex of young and aged mice by using high-density oligonucleotide arrays. A number of key genes involved in neurona...
Growing evidence has shown that proNGF-p75NTR-sortilin signaling might be a crucial factor in neurodegeneration, but it remains unclear if it may function in nigral neurons under aging and disease. The purpose of this study is to examine and quantify proNGF and sortilin expression in the substantia nigra and dynamic changes of aging in lactacystin and 6-hydroxydopamine (6-OHDA) rat models of Pa...
Little is known about the time course of aging on interstitial cells of Cajal (ICC) of colon. The aim of this study was to investigate the change of morphology, ICC, and neuronal nitric oxide synthase (nNOS)-immunoreactive cells in the aged rat. The proximal colon of 344 Fischer rats at four different ages (6, 31, 74 wk, and 2 yr) were studied. The immunoreactivity of c-Kit, nNOS, anti-protein ...
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