Efforts to take advantage of the beneficial activities of thyrotropin-releasing hormone (TRH) in the brain are hampered by its poor metabolic stability and lack of adequate central nervous system bioavailability. We report here novel and metabolically stable analogs that we derived from TRH by replacing its amino-terminal pyroglutamyl (pGlu) residue with pyridinium-containing moieties. Explorat...

Significant levels of flavonoids with antioxidant properties can be found in citrus species. Flavonoids are a class plant chemical known for wide range pharmacological activities. Notable among these is Hesperidin. It has quite number biological properties, like anti-inflammatory and properties. Numerous studies have examined the impacts hesperidin its underlying mechanisms throughout last few ...

The aim of the present study was to assess the toxic potential of drugs of abuse and other neuropharmacological agents in the pathogenesis of AIDS dementia complex (ADC), the neurological complication of AIDS. Neuroblastoma and glioblastoma cell lines expressing the dopamine transporter, as well as primary macrophages exposed to human immunodeficiency virus-1 (HIV-1), were used to investigate t...

Repeated treatment of psychotropic drugs produces changes in brain and behavior that far outlast their initial neuropharmacological effects. The nature of persistent drug-induced neural plasticity is of interest because it is thought to contribute to the development of drug dependency and addiction. To determine if chronic morphine treatment alters the morphology of visual cortical neurons, we ...