Outcomes for patients with refractory diffuse large B cell lymphoma (DLBCL) are poor. In the multicenter ZUMA-1 phase 1 study, we evaluated KTE-C19, an autologous CD3ζ/CD28-based chimeric antigen receptor (CAR) T cell therapy, in patients with refractory DLBCL. Patients received low-dose conditioning chemotherapy with concurrent cyclophosphamide (500 mg/m2) and fludarabine (30 mg/m2) for 3 days...

(tacrolimus) are potent immunosuppressive agents that are widely used in organ transplantation of the kidney. However, these agents can induce neurotoxicity. The spectrum of neurological disturbances caused by calcineurin inhibitors ranges from very mild symptoms such as paresthesia, tremor, headache and flushing to severe changes that may cause a lethal outcome (1, 2). The neurotoxicity of the...