OBJECTIVES Customarily used classification of IPF did not satisfy a sizable group of patients with IPF that in the past had been lumped with UIP and now currently has begun to be recognized as nonspecific interstitial pneumonia/fibrosis (NIP). There are few reports about the clinical features of NIP. METHODS The pathologic slides of 66 patients having open lung biopsy (OLB) for the differenti...

Abstract In continuous casting of steel, the strand is cooled in upper part secondary cooling zone with water sprayed by nozzles towards surface. The accumulates nip lower roll a pair, forming pool which then drains off ends roll. present work, open channel hydraulics was applied for computation height between and slab casting. differential equation describing change spatially varied flow incre...

PURPOSE To evaluate the effect of parecoxib (an NSAID) on renal function by measuring plasma NGAL (serum neutrophil gelatinase-associated lipocalin) levels in an induced-ischemia rat model. METHODS Forty male Wistar rats were randomly assigned to one of four groups: Ischemia (I), Ischemia/parecoxib (IP), No-ischemia (NI), and No-ischemia/parecoxib (NIP). Body weight, mean arterial pressure, h...

A three-phase ensemble-averaged model is developed for the flow of water and air through a deformable porous matrix. The model predicts a separation of the flow into saturated and unsaturated regions. The model is closed by proposing an experimentally-motivated heuristic elastic law which allows large-strain nonlinear behaviour to be treated in a relatively straightforward manner. The equations...

Chiral recognition of DNA molecules is important because DNA chiral transition and its different conformations are involved in a series of important life events. Among them, polymorphic human telomere DNA has attracted great interests in recent years because of its important roles in chromosome structural integrity. In this report, we examine the short-term effect of chiral metallo-supramolecul...

Cardiac connexin 43 (Cx43) is involved in infarct propagation, and the uncoupling of Cx43-formed channels reduces infarct size. Cx43-formed channels open upon Cx43 dephosphorylation, and ischemic preconditioning (IP) prevents the ischemia-induced Cx43 dephosphorylation. In addition to the sarcolemma, Cx43 is also present in the cardiomyocyte mitochondria. We now examined the interaction of Cx43...

The proteasome inhibitor bortezomib is approved for the treatment of multiple myeloma and mantle cell lymphoma. We recently demonstrated that bortezomib eliminates autoreactive plasma cells in systemic lupus erythematosus mouse models, thereby representing a promising novel treatment for Ab-mediated diseases. In this study, we investigated the effects of bortezomib on the just developing and pr...