Background and Objective: Cardiovascular disorders continue to constitute major causes of morbidity and mortality in diabetic patients. In this study, the effect of chronic administration of Tribulus terrestris (TT) feeding was studied on aortic reactivity of streptozotocin (STZ)-diabetic rats and some underlying mechanisms were investigated.    Materials and Methods: Male diabetic rats receive...

Bacterial lipopolysaccharide and some cytokines can activate macrophages to secrete nitric oxide. Macrophage-derived nitric oxide is a key cytotoxic factor for microbicidal and tumoricidal processes. We report here that a monoclonal antibody specific for beta interferon inhibited lipopolysaccharide-induced nitric oxide production in thioglycolate-elicited C3HeB/FeJ peritoneal macrophages and ma...

With respect to the ambient nitric oxide values, we have examined their effect on exhaled nitric oxide. Since there was no significant influence of ambient nitric oxide levels ,20 ppb on the fraction of exhaled nitric oxide values in our study population (figs 2 and 3), we decided to include all children with ambient nitric oxide levels ,20 ppb in the analyses. When the analyses were repeated, ...

Nitric oxide was largely regarded as a toxic pollutant until 1987, when its biologic similarities to endothelium-derived relaxing factor were demonstrated.1 Subsequently, nitric oxide and endothelium-derived relaxing factor were considered a single entity, modulating vascular tone through the stimulated formation of cyclic guanosine 3',5'-monophosphate (Fig. 1).2 Endogenous nitric oxide is form...

The metabolism of nitric oxide in Paracoccus denitrificans has been studied using a Clark-type electrode. The uncoupler carbonyl cyanide m-chlorophenylhydrazone (CCCP) and the SH reagent N-ethylmaleimide, both of which released nitric oxide from cells respiring nitrite, were found to be efficient inhibitors of nitric oxide reductase activity. Control experiments with another uncoupler, pentachl...

BACKGROUND Bypass graft disease is related to proliferation and migration of vascular smooth muscle cells and to platelet activation with thrombus formation. Nitric oxide inhibits these biological responses; it has never been demonstrated, however, whether this occurs in intact human vascular tissue after endothelial nitric oxide synthase gene transfer. METHODS We examined whether endothelial...

this study aimed to identify the relationship between fractional exhaled nitric oxide (feno) level and potential factors in non-asthmatic children from shanghai, china. from march to april 2012, the school-aged children fulfilling the inclusion criteria were recruited. the feno levels of non-asthmatic children were detected by the nano coulomb nitric oxide analyzer. questionnaires were recorded...

introduction: accumulating evidences indicated that during increasing of the animals' age, the number and the functional properties of hematopoietic stem cells (hscs) become altered because of a gradual decrease in replication potential.  the efficient factors in this process are dna damaging, reduced telomerase activity, shortening of telomeres and oxidative stresses. for overcoming these fact...

objective(s): an increase in nitric oxide (no) production has been reported in cirrhotic cardiomyopathy and, portal hypertension. since minocycline has been shown to inhibit no overproduction, we aimed to examine its role in a rat model of ccl4-induced cirrhotic cardiovascular complications. materials and methods: portal pressure and inotropic responsiveness of isolated papillary muscles to iso...

objective(s) the liver has major role in the organism homeostasis, interactions with other systems, synthesis and metabolism of bile production, drug detoxification and hormone inactivation. cholestasis can be defined as an impairment of the bile flow which can lead to hepatocytes necrosis and finally cirrhosis. some studies reported a gastric acid secretion reduction in cirrhotic subjects, whi...