OBJECTIVES Recent evidence have proposed that Tretinoin produced in the gut preferentially promote differentiation of FoxP3+Treg cells but inhibits Th17 lymphocytes, and this may be the main immunomdulatory mechanism of Tretinoin in vivo. This study was done to investigate the effects of Tretinoin in outbred white mice after challenge with sheep red blood cells (SRBC). MATERIALS AND METHODS T...

PL-10.1.AK-15 is an active fragment of a naturally occurring protein first isolated from human gastric juice. Among its other protective effects, PL-10.1.AK-15 has demonstrated a protective effect on the gastrointestinal tract. The aim of this study was to investigate the influence of PL-10.1.AK-15 on two functional parameters of gastrointestinal function: gastric acid secretion and gastrointes...

The most critical bottleneck in the generation of recombinant Plasmodium berghei parasites is the mandatory in vivo cloning step following successful genetic manipulation. This study describes a new technique for rapid selection of recombinant P. berghei parasites. The method is based on flow cytometry to isolate isogenic parasite lines and represents a major advance for the field, in that it w...

Biofiltration is one of the air pollution control technologies that utilizes the microorganisms to biologically degrade Volatile Organic Compounds (VOCs) and odor contained in waste air streams. The microorganism exists on the surface and in a thin water film surrounding the surface of biofilter material and degrades the pollutants present in the fluid. This method is distinguished from other b...

In a small sample of 57 retrovirus integration sites (RISs) isolated from 23 end-stage lymphomas induced in NMRI mice by the B-lymphotropic Akv wt or an enhancer mutant hereof, Akv1-99, we identified 14 novel RISs and defined 9 novel CISs (common insertion sites). Moreover, when comparing with RISs from tumors induced by the T-lymphomagenic SL3-3, we observed that SL3-3 targets RefSeq promoter ...

During the past years, special emphasis was put on medical preparedness in the event of radiological or nuclear emergencies. Novin Medical Radiation Institute (NMRI) encouraged and supported the national authorities to enhance their cooperation in improving medical response to radiation accident. NMRI in cooperation with International Atomic Energy Agency (IAEA) and Atomic Energy Organization o...