For many years, the presence of yessotoxins (YTXs) in shellfish has contributed to the outcome of the traditional mouse bioassay and has on many occasions caused closure of shellfisheries. Since YTXs do not appear to cause diarrhoea in man and exert low oral toxicity in animal experiments, it has been suggested that they should be removed from regulation. Before doing so, it is important to det...

objective(s): progestrone is a prequisite for pre-implantation angiogenesis and induce decidual angiogenesis. it is unknown the effect of progestrone administration on the endometrium of hyperstimulated mice at pre-implantation time. material and methods: adult female nmri mice were divided in three groups [control group, ovarian stimulated group and progestrone treated mice after ovarian stimu...

Objective(s):  This study was undertaken to investigate the protective effects of vitamin B6, cofactor for cystathionine-γ lyase and cystathionine-β synthase (producers of H2S), alone and in combination with L-cysteine, H2S precursor, on indomethacin-, and ethanol-induced gastric lesions in male NMRI mice. Materials and Methods: Fasted male NMRI mice were randomly assigned into 12 groups (7 in ...

background: we evaluated the in vivo activity of bunium persicum (boiss) essential oil on infected mice with acute toxoplasmosis. methods: to evaluate prophylactic effects, male nmri mice received b. persicum essential oil at the concentrations of 0.05 and 0.1 ml/kg for 14 days . after 24 h mice were infected intraperitonealy with 1×10 4 tachyzoites of t. gondii, rh strain. in order to investig...

Automated blood sampling through a vascular catheter is a frequently utilized technique in laboratory mice. The potential immunological and physiological implications associated with this technique have, however, not been investigated in detail. The present study compared plasma levels of the cytokines IL-1β, IL-2, IL-6, IL-10, IL-17A, GM-CSF, IFN-γ and TNF-α in male NMRI mice that had been sub...

Objective Crocin is an active ingredient of saffron (Crocus sativus L.) and its antioxidant properties have been previously investigated. This carotenoid scavenges free radicals and stimulates glutathione (GSH) synthesis; consequently, it may protect cells against oxidative stress. The aim of this research is to protect oocytes from oxidative stress by the addition of a natural source antioxida...