BACKGROUND AND PURPOSE Microvascular perfusion defects may accompany sustained occlusion and subsequent reperfusion of the middle cerebral artery; however, the nature of such "no-reflow" defects remains unclear. METHODS In the absence of antithrombotic pretreatment, we documented lenticulostriatal microvascular flow integrity following 3-hour middle cerebral artery occlusion and 1-hour reperf...

Potential mechanisms of perilipin 2 in angiographic no-reflow = coronary no reflow.

The brain regulates blood flow to match energy demand to nutrient supply. In this issue of Neuron, using in vivo optical imaging and optogenetics, Hill et al. (2015) report that arteriolar smooth muscle cells are key players in regulating cerebral blood flow in the healthy state and contribute to the "no reflow" phenomenon after ischemic stroke.

Thromb Haemost 2005; 94: 693–4 Coronary no-reflow is a rare but potentially devastating complication that can occur during percutaneous coronary interventions (PCI). It is defined as the lack of passage of contrast dye into the microvasculature despite relief of the original obstruction in the epicardial vessel and is an angiographic marker of impaired myocardial perfusion at the tissue level (...

One hypothesis on the pathogenesis of post-ischemic-anoxic encephalopathy is impaired cerebral perfusion or the no-reflow phenomenon. Therapies aimed at preventing the development of this phenomenon are increased cerebral perfusion pressure (CPP) and hyperventilation or hypercapnia. Using a dog model in which we have described the progressive development of post-ischemic (PI) cerebral hypoperfu...

OBJECTIVE To investigate the effects of tirofiban on the no-reflow phenomenon of acute myocardial infarction (AMI) rats received reperfusion, as well as the underlying mechanisms. METHODS Fifty-six male Sprague-Dawley rats were randomly divided into four groups: Sham operation group (Sham), AMI/reperfusion group (AMI/R), Tirofiban group (Tiro) and Tiro+N-nitro-L-arginine group (L-NNA; an endo...

Abstract Introduction The no-reflow phenomenon is a serious complication of coronary intervention, especially in primary angioplasty and effective preventive measures are unknown. Methods Retrospective study all patients treated by single center through 4 years. We define as the absence flow immediately after stent angioplasty. variables associated with this were analyzed using binary logistic ...

background: due to the positive relation between platelet size and platelet reactivity, a high value of the mean platelet volume (mpv) is an independent risk factor to predict acute myocardial infarction (ami) and its adverse outcome. few data are available to determinate the prognostic value of mpv in st-elevation myocardial infarction (stemi) patients treated with percutaneous coronary interv...