Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an uncommon entity that, in contrast to classical Hodgkin lymphoma (cHL), universally expresses CD20, a hallmark of the disease. The majority of the patients present with early-stage disease, and treatment with local radiation provides excellent disease control and overall survival (OS). For locally extensive or advanced stages, paradig...

Aim: Classical Hodgkin lymphoma is common, it one of the lymphomas whose differential diagnosis can be difficult. It thought that cell may originate from germinal center. Our aim in this study was to determine center transformation markers OCT-2, BOB.1, BCL-6, PAX-5, CD20 and MUM-1 Classic Lymphoma (CHL), Nodular Lymphocyte Predominant (NLPHL) Diffuse Large B-cell (DLBCL) evaluate expressions b...

Purpose
 Several studies suggest that the relation of Epstein-Barr virus (EBV) and Hodgkin lymphoma (HL). EBV HL associations are reported at rates ranging from 20% to 100% varies nationally regionally. In this study; in case Hodgkin's lymphoma, presence encoded RNA (EBER) by situ hybridization method it’s distribution according histopathological subtypes were investigated. 
 Methods&...

The etiology of Hodgkin lymphoma (HL) is poorly understood, and studies of the genetics of this disease have been hampered by the scarcity of the Hodgkin and Reed-Sternberg (HRS) cells within tumors. To determine whether recurrent genomic imbalances are a feature of HL, CD30-positive HRS cells were laser-microdissected from 20 classical Hodgkin lymphomas (cHLs) and four HL-derived cells lines a...

Due to disease rarity, there is limited information regarding the optimal therapy and outcome for patients with advanced-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Forty-two patients with NLPHL by the Revised European-American Lymphoma/World Health Organization classification with advanced-stage disease were identified and paired 1:2 with a matched control with classical Hod...

ing factors IκBα and A20 are uncommon in nodular lymphocyte-predominant Hodgkin lymphoma. Haematologica. 2010; 95(1):153-7. 35. Monti S, Savage KJ, Kutok JL, Feuerhake F, Kurtin P, Mihm M, et al. Molecular profiling of diffuse large B-cell lymphoma identifies robust subtypes including one characterized by host inflammatory response. Blood. 2005;105(5):1851-61. 36. Lenz G, Wright G, Dave SS, Xia...