The zinc metalloprotease, neprilysin (NEP), plays a role in the metabolism of cardiovascular, inflammatory and neuropeptides, including mitogenic peptides such as bombesin. In the cardiovascular system, NEP has a primary role in the inactivation of natriuretic peptides but also contributes to local metabolism of angiotensin, endothelins and bradykinin. Hence NEP is seen as a potential therapeut...

background : cement industry has many process units. basically all of these units can be considered as a source of noise. since noise pollution is defined based on its offensive hearing effects, the importance of the noise sources depends directly on the number of workers in the unit.   materials and methods : an experimental study has been done at tehran cement factory to recognize and analyze...

We determine the optimal adaptive rate and power control strategies to maximize the total throughput in a multirate code-division multiple-access system. The total throughput of the system provides a meaningful baseline in the form of an upper bound to the throughput achievable with additional restrictions imposed on the system to guarantee fairness. Peak power and instantaneous bit energy-to-n...

The equilibrium problem with equilibrium constraints (EPEC) can be looked on as a generalization of Nash equilibrium problem (NEP) and the mathematical program with equilibrium constraints (MPEC) whose constraints contain a parametric variational inequality or complementarity system. In this paper, we particularly consider a special class of EPECs where a common parametric P-matrix linear compl...

We investigate thermal noise mechanisms and present analytical expressions of the noise power spectral density at high frequencies (HF) in Silicon-on-insulator (SOI) MOSFETs. The developed HF noise model of RF T-gate body contact (TB) SOI MOSFET for 0.13-μm SOI CMOS technology accounts for the mechanisms of 1) channel thermal noise; 2) induced gate noise; 3) substrate resistance noise and 4) ga...

Copper plays a central role in conserved processes such as respiration, and in highly specialized processes, such as protein modification. The metalloprotease neprilysin (NEP) degrades a variety of bioactive peptides and is involved in many physiological processes. However, very little is known about the regulation of NEP activity. In the current study, we focused on the effect of Cu2+ on the e...

Background: Ototoxic chemicals can impair the sense of hearing and balance. In the past decades, the ototoxicity of solvents and their interaction with noise have become evident. This study has been carried out in the shoe manufacturing factory in Tehran (Iran) with the aim of evaluating the combined effects of noise and toluene on the workers' hearing. Materials and Methods: This cross-sect...