non alcoholic steatohepatitis

Non-Alcoholic Fatty Liver Disease (NAFLD) is termed as the accumulation of extra fat in hepatic cells and it is mainly associated with obesity and insulin resistance [1]. NAFLD is very common in the general population and almost up to 29% of the adults are documented with excessive fat accumulation in the liver [2]. NAFLD encompasses a histological spectrum ranging from simple steatosis to non-...

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HIV Induces TRAIL Sensitivity in Hepatocytes

Journal: :PLoS ONE 2009

Challagundla K. Babu Kanitta Suwansrinon Gary D. Bren Andrew D. Badley Stacey A. Rizza

BACKGROUND HIV infected patients have an increased susceptibility to liver disease due to Hepatitis B Virus (HBV), Hepatitis C Virus (HCV), alcoholic, and non-alcoholic steatohepatitis. Clinically, this results in limited options for antiretroviral therapy and accelerated rates of liver disease, causing liver disease to be the second leading cause of death for HIV infected patients. The mechani...

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