Purpose. Secondary hyperparathyroidism with nodular hyperplasia is resistant to medical therapies. Cinacalcet is an effective treatment for severe secondary hyperparathyroidism. This multicentre retrospective study was designed to determine the long-term efficacy of cinacalcet in patients with nodular hyperplasia, the advanced type of parathyroid hyperplasia. Subjects and methods. The study sub...

BACKGROUND Bile reflux is one of the primary factors involved in the pathogenesis of gastric mucosal lesions in patients with chronic gastritis; however, little is known about the exact histological features of bile reflux and its contributions to gastric mucosal lesions in this disease, especially in children with primary bile reflux gastritis (BRG). The aim of this study was to investigate th...

Natural Computing (NC) is an emerging field in formal language theory, which is mainly focused on the computing capabilities of formal devices that abstract some natural complex phenomena. These bio-inspired models include both, classic computing devices (such as cellular automata, Lindenmayer systems, DNA computing, evolutionary computation, Multi-agent systems or artificial neural networks) a...

Abstract The therapeutic effect and action mechanism of solubilized Sturgeon oil (SSO) against atopic dermatitis (AD) were examined in NC/Nga mice. SSO was prepared from the fish obtained Sturgeons using physical solubilization processes. AD induced by topical application house dust mite (HDM) extract on dorsal skin mice, then treated with SSO. exerted potent activity symptoms. Histological ana...

The diagnosis of polycythemia vera (PV) requires the integration of clinical and laboratory findings, bone marrow morphologic features, and JAK2 analysis. JAK2(V617F) (exon 14) mutation is found in 95% of PV cases. Functionally similar mutations in JAK2 exon 12 have also been described, but a thorough bone marrow study has not been done. We identified 7 PV cases with exon 12 mutations; all had ...

CONTEXT We undertook this study to estimate the prevalence of the various androgen excess disorders using the new criteria suggested for the diagnosis of polycystic ovary syndrome (PCOS). SETTING The study was performed at two endocrine departments at the University of Palermo (Palermo, Italy). PATIENTS The records of all patients referred between 1980 and 2004 for evaluation of clinical hy...