Raft-dependent endocytosis is in large part defined as the cholesterol-sensitive, clathrin-independent internalization of ligands and receptors from the plasma membrane. It encompasses the endocytosis of caveolae, smooth plasmalemmal vesicles that form a subdomain of cholesterol and sphingolipid-rich lipid rafts and that are enriched for caveolin-1. While sharing common mechanisms, like cholest...

Problem statement. The patented useful model for the design of combined raft-pile foundation (CRPF), consisting a raft part and piles, with gap height Δ is made between piles. That is, distribution settlements (resistances) soil base under then piles (after hinged connection raft) assumed, based on condition not exceeding maximum allowable settlement su building or structure. initial which aris...

The small intestinal brush border has an unusually high proportion of glycolipids which promote the formation of lipid raft microdomains, stabilized by various cross-linking lectins. This unique membrane organization acts to provide physical and chemical stability to the membrane that faces multiple deleterious agents present in the gut lumen, such as bile salts, digestive enzymes of the pancre...

Our earlier studies have shown that Kir2.x channels are suppressed by an increase in the level of cellular cholesterol, whereas cholesterol depletion enhances the activity of the channels. In this study, we show that Kir2.1 and Kir2.3 channels have double-peak distributions between cholesterol-rich (raft) and cholesterol-poor (non-raft) membrane fractions, indicating that the channels exist in ...

the pile-raft foundation is a combination of a raft foundation with piles. pile-raft foundation has been widely designed, assuming all structure loads to be transferred to piles without considering contribution of the load taken by contact surface between raft and soil. methods of analysis currently used in practice are based upon relatively conservative assumptions of soil behavior or on the l...