In 1986, a population study of school children in the city of Coventry gave an overall prevalence in males and females for fragile X syndrome of 1/952. The 29 children diagnosed as having fragile X syndrome in this study have been re-evaluated with molecular diagnostic techniques. Eighteen of the original 29 children have been found not to have the expansion of the FMR1 gene associated with fra...

A recently developed atomistic method capable of calculating the fragile (non-Arrhenius) temperature behavior of highly viscous liquids is further tested by studying a model of SiO(2), a glass former well known for its Arrhenius temperature behavior (strong). The method predicts an Arrhenius temperature variation, in agreement with experiments, the origin of which is revealed by both quantitati...

Fragile watermarking techniques for digital content have been studied in the past few years. Fragile watermarks are used to determine if a piece of watermarked digital content has been tampered, and distinguish tampered areas from non-tampered areas without referring to the original digital content. In this paper, a general framework for fragile watermark is proposed, and then a novel fragile w...

As complex socio-technical systems composed of many interconnected parts, interacting in non-linear, dynamic, emergent and often unexpected ways Information Systems are fragile. In this paper we introduce the concept of antifragility as an alternative mean of apprehending the fragility of Information Systems and a novel way of dealing with risk, uncertainty and the unknown. Antifragility is the...

Watermark is an information-carrying signal embedded into digital data that can be extracted later to make some assertion about the data. Digital watermarks are usually classified as robust or fragile. Robust watermarks are designed to resist most image manipulating procedures and are used normally to attest the image ownership. Fragile watermarks are easily corrupted by any image processing pr...

Fragile X syndrome, a common form of inherited mental retardation, is caused by the loss of fragile X mental retardation protein (FMRP). We have previously demonstrated that dFmr1, the Drosophila ortholog of the fragile X mental retardation 1 gene, plays a role in the proper maintenance of germline stem cells in Drosophila ovary; however, the molecular mechanism behind this remains elusive. In ...

Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of expression of the Fragile X Mental Retardation Protein (FMRP), an RNA binding protein with high specificity for G-quartet RNA structure. FMRP is involved in several steps of mRNA metabolism: nucleocytoplasmic trafficking, translational control and transport along dendrites in neurons. Fragile X ...

Fragile X syndrome, the most frequent form of inherited mental retardation, is due to the absence of expression of the Fragile X Mental Retardation Protein (FMRP), an RNA binding protein with high specificity for G-quartet RNA structure. FMRP is involved in several steps of mRNA metabolism: nucleocytoplasmic trafficking, translational control and transport along dendrites in neurons. Fragile X ...