Piracetam, a derivative of γ-aminobutyric acid, exerts memory-enhancing and mild anxiolytic effects in human and rodent studies. To examine the drug's behavioral profile further, we assessed its effects on behavioral and endocrine (cortisol) responses of adult zebrafish (Danio rerio)--a novel model species rapidly gaining popularity in neurobehavioral research. Overall, acute piracetam did not ...

The principle of this method was to screen the pharmacological activity of six prepared polyphyto formulations by using high throughput screening method for their nootropic action. The study was performed in three stages using one, two and three animals, respectively in a group. Test formulations were given p.o daily at the dose of 50 and 100 mg/kg body weight. The test formulations were compar...

OBJECTIVE Parkia biglobossa stem bark decoction is a popular medicinal plant preparation used as calming agent for tensed patients in traditional medicine. The aim of this study was to evaluate the effects of aqueous stem bark extract of Parkia biglobossa (AEPB) and its active fraction AEPBF3 on anxiety, spontaneous alternation behavior, and locomotor activity. The open field apparatus was used...

Levetiracetam, the alpha-ethyl analogue of the nootropic piracetam, is a widely used antiepileptic drug (AED) that provides protection against partial seizures and is also effective in the treatment of primary generalized seizure syndromes including juvenile myoclonic epilepsy. Levetiracetam was discovered in 1992 through screening in audiogenic seizure susceptible mice and, 3 years later, was ...

Alzheimer’s disease is the most frequent type of life threatening dementia which is characterized by oxidative stress and inflammation induced neuronal loss, impaired energy metabolism, and cholinergic deficits leading to severe cognitive impairments and other abnormal neuropsychiatric changes. Cure of cognitive disorders such as amnesia, attention deficit and Alzheimer’s disease is still a nig...

This study aimed to investigate the beneficial effects of tocotrienols (T3) supplementation on one’s attention and memory. Eleven healthy subjects were enrolled receive placebo followed by T3 in 6 weeks. Psychomotor Vigilance Task (PVT) Digit Span Test (DST) used access subjects’ sustained working Electroencephalogram (EEG) was examine brainwave activity. significantly improved memory relative ...