Nearly half a century after the first report of normal pressure hydrocephalus (NPH), the pathophysiological cause of the disease still remains unclear. Several theories about the cause and development of NPH emphasize disease-related alterations of the mechanical properties of the brain. MR elastography (MRE) uniquely allows the measurement of viscoelastic constants of the living brain without ...

Normal pressure hydrocephalus (NPH) is a relatively common disease of adulthood characterized by a typical combination of clinical and radiological findings. In this report, we discuss a 54-year-old female presenting with symptoms suggestive of NPH and found to have a history of human immunodeficiency virus (HIV) type 1. She was not treated as she was in denial state and developed NPH as a poss...

The cerebrospinal fluid tap test (CSFTT) is recommended as a key step in the diagnosis of idiopathic normal pressure hydrocephalus (iNPH). While there is no generally accepted evaluation period for ascertaining a CSFTT responder, a substantial number of patients are evaluated only once within 24 hours of the test for improvement in gait. We report an iNPH patient with a favorable response to sh...

1.1 Purpose Normal pressure hydrocephalus (NPH) is a neurologic disorder that causes three groups of progressive symptoms that are very disabling: gait and balance problems leading to falls, urinary incontinence, and dementia. This condition is in urgent need of clarification, because while the diagnosis of NPH is very difficult to make with confidence, the gait and postural instability caused ...

BACKGROUND/AIMS Postural instability in patients with normal pressure hydrocephalus (NPH) is a most crucial symptom leading to falls with secondary complications. The aim of the current study was to evaluate the therapeutic effect of spinal tap on postural stability in these patients. METHODS Seventeen patients with clinical symptoms of NPH were examined using gait scale, computerized dynamic...

Magnetic resonance imaging (MRI) can depict not only anatomical information, but also physiological factors such as velocity and pressure gradient. Measurement of these physiological factors is necessary to understand the cerebrospinal fluid (CSF) environment. In this study we quantified CSF motion in various parts of the CSF space, determined changes in the CSF environment with aging, and comp...

BACKGROUND The purpose of this study is to investigate the epidemiology of the idiopathic normal pressure hydrocephalus (iNPH) in Germany. METHODS The database of the nationwide Barmer Health Insurance was queried for specific combinations of corresponding International Classification of Diseases, Ninth Revision (ICD-9) codes and OPS codes (German modification of the ICPM and official classif...

We model the impact of atmospheric turbulence-induced phase and amplitude fluctuations on free-space optical links using synchronous detection. We derive exact expressions for the probability density function of the signal-to-noise ratio in the presence of turbulence. We consider the effects of log-normal amplitude fluctuations and Gaussian phase fluctuations, in addition to local oscillator sh...

BACKGROUND AND PURPOSE MR studies have shown hippocampal atrophy to be a sensitive diagnostic feature of Alzheimer's disease (AD). In this study, we measured the hippocampal volumes of patients with a clinical diagnosis of normal pressure hydrocephalus (NPH), a potentially reversible cause of dementia when shunted. Further, we examined the relationship between the hippocampal volumes and cortic...

Sandra L. Siedlecki, PhD, RN, CNS AbstrAct Although normal pressure hydrocephalus (NPH) is a potentially treatable neurological condition, many individuals with NPH will never receive treatment because the diagnosis is missed and the symptoms are attributed to other disorders. Left untreated, NPH causes significant physical and emotional suffering and eventually leads to premature death. It is ...