introduction: the diagnosis of the origin of the lesions is one of the basic problems in endo-perio lesion. in order to prevent unnecessary and harmful treatment, the accurate diagnosis must be developed. the aim of this study was to evaluate the effect of advanced periodontal diseases on pulp tissue. methods and materials: in this experimental study, fourty two anterior teeth were extracted fr...

Gastric adenocarcinoma (GC), the second most frequent cancer in the world, is highly prevalent in Asia. A screening test for early-stage GC would represent a major advance in the management of this disease. Associated conditions such as chronic atrophic gastritis (CAG) with intestinal metaplasia are manifested by specialized intestinalized tissue that often includes Paneth cells. Adenoma-associ...

Psoriasis is a common chronic, inflammatory and proliferative skin disease that is widely associated with multiple factors under a polygenic background. The expression of hypoxia-inducible factor-1α (HIF-1α), macrophage migration inhibitory factor (MIF), cyclooxygenase-2 (COX-2) and vascular endothelial growth factor (VEGF) is associated with psoriasis; however, there have been no systematic st...

Capabilities of diffusion-weighted (DW) and magnetization transfer (MT) imaging are well established for tissue characterization in various pathologies individually. However, the effect of suppression of macromolecules on applying MT pulse on signals associated with DW imaging and resulting change in the apparent diffusion coefficient (ADC) of water molecules has not been demonstrated previousl...

Psoriasis is a hyperproliferative inflammatory skin disease; therefore, it is highly likely that psoriatic skin lesions may transform into malignancies. However, malignant transformation is not common. We performed immunohistochemical studies using anti‑cyclin D1, anti‑cyclin E, anti‑pRb, anti‑p53, anti‑p16INK4a, and anti‑Ki‑67 antibodies in normal skin, psoriatic epidermal tissue, and squamous...

The objective was to evaluate the performance of a high-definition multileaf collimator (MLC) of 2.5 mm leaf width (MLC2.5) and compare to standard 5 mm leaf width MLC (MLC5) for the treatment of intracranial lesions using dynamic conformal arcs (DCA) technique with a dedicated radiosurgery linear accelerator. Simulated cases of spherical targets were created to study solely the effect of targe...

UNLABELLED The aim of the present study was to characterise the expression pattern of claudin-7 tight junction protein in canine normal liver, hyperplastic and primary neoplastic lesions of the canine liver and whether this tight junction protein can help differentiate canine cholangiocarcinomas from canine hepatocellular carcinomas. METHODS AND RESULTS Necropsy samples included 15 canine nor...

Bone is a dense connective tissue which is being aff ected by many diseases and that is independent of any age limits. Fibro-osseous lesions consist of the normal bone is being substituted by benign fi brous tissue comprising varying amount of mineralization which characteristically aff ect jaws and the craniofacial bone pathology.

Deformable registration of magnetic resonance images between patients with brain tumors and healthy subjects has been an important tool to specify tumor geometry through location alignment facilitate pathological analysis. Since region does not match any ordinary tissue, it difficult deformably register a patient’s normal one. Many patient are associated irregularly distributed lesions, resulti...