ticenter comparison of two norovirus ORF2-based genotyping protocols.multaneous detection and identifi cation of hepatitis A virus and rotavirus by mul-tiplex nucleic acid sequence-based am-plifi cation (NASBA) and microtiter plate hybridization system. Use of norovirus genotype profi les to differentiate origins of foodborne outbreaks. Estimation of norovirus infection risks to consumers of wa...

Noroviruses are an important cause of acute gastroenteritis in humans. We incorporated new insights gained over the past decade in an updated estimate of the disease burden of (foodborne) norovirus illness in The Netherlands in 2009. The disease outcomes - non-consulting cases, visiting a general practitioner, hospitalization and mortality - and the foodborne proportion were derived from cohort...

We investigated a norovirus outbreak (genotype GII.2) affecting 9 members of a soccer team. Illness was associated with touching a reusable grocery bag or consuming its packaged food contents (risk difference, 0.636; P < .01). By polymerase chain reaction, GII norovirus was recovered from the bag, which had been stored in a bathroom used before the outbreak by a person with norovirus-like illne...

Histo-blood group antigens (HBGAs) are important binding factors for norovirus infections. We show that two human milk oligosaccharides, 2'-fucosyllactose (2'FL) and 3-fucosyllactose (3FL), could block norovirus from binding to surrogate HBGA samples. We found that 2'FL and 3FL bound at the equivalent HBGA pockets on the norovirus capsid using X-ray crystallography. Our data revealed that 2'FL ...

Feline calicivirus is one of the surrogate viruses human norovirus. This study aimed to identify virucidal compounds, chemical constituents plants from genus Dracocephalum, which are rich in flavonoids and phenylpropanoid oligomers. Four undescribed including a flavanone glucoside, two stilbenoid glycosides, amide glycoside, as well 17 known were isolated Mongolian Dracocephalum fruticulosum St...

BACKGROUND Chronic diarrhea in patients treated with immunosuppressive agents or suffering from immunosuppressive disease can represent a diagnostic and therapeutic challenge to the clinician. Norovirus infection, a major cause of acute epidemic diarrhea, has been described as a cause of chronic diarrhea in patients who are immunosuppressed, including transplant recipients and the very young. ...

Human norovirus are major causative agent of nonbacterial acute gastroenteritis. In general, genogroup (G) II.4 is the most prominent major genotype that circulate in human population and the environment. However, a shift in genotypic trends was observed in Korea in December 2014. In this study, we investigated the trend of norovirus genotype in detail using the database of Acute Diarrhea Labor...

Human noroviruses are the primary causative agents of acute gastroenteritis and a pressing public health burden worldwide. There are currently no vaccines or small molecule therapeutics available for the treatment or prophylaxis of norovirus infections. Norovirus 3CL protease plays a vital role in viral replication by generating structural and nonstructural proteins via the cleavage of the vira...

aim : the aim of this study is to determine the prevalence and genotype of human caliciviruses among children suffering from acute gastroenteritis referred to masih daneshvari hospital. background : human caliciviruses have been recognized as the major viral cause of acute gastroenteritis in all age groups worldwide. studies revealed that the noroviruses and sapoviruses could be divided into fi...

Foodborne outbreaks associated with transmission of norovirus are increasingly becoming a public health concern. Foods can be contaminated faecal material at the point production or during food preparation, in both home and commercial premises. Transmission occurs through faecal-oral route, either via person-to-person contact faecal-contamination food, water, environmental surfaces. Understandi...