Aging is one major risk factor for numerous diseases. The enzyme telomerase reverse transcriptase (TERT) plays an important role for aging and apoptosis. Previously, we demonstrated that inhibition of oxidative stress-induced Src kinase family-dependent nuclear export of TERT results in delayed replicative senescence and reduced apoptosis sensitivity. Therefore, the aim of this study was to inv...

This paper briefly reviews the literature on family structure, dynamics and relationships between family-jointness and different psychiatric disorders in India. Many recent studies indicate that the nuclear families are more vulnerable and plea is made for maintaining the traditional joint family system, even in some modified forms, because of its "built-in-immunity" and supportive networks.

SOL1, the founding member of the S. cerevisiae SOL family, was previously identified as a multi-copy suppressor of the los1 defect in tRNA-mediated nonsense suppression. Here we report that the four-member SOL family is not essential and that individual family members appear to have distinct functions. SOL1-SOL4 are homologous to genes encoding 6-phosphogluconolactonase (6Pgl) involved in the p...

Grandparents are family members and form an important element of the extended family. In traditional cultures, grandparents often have a direct and clear role in relation to the care and nurture of children. This has tended to be lost with the development of the nuclear family. In cases where the parents are not willing or unable to provide adequate care for their children, grandparents may tak...

PURPOSE To report the identification of a novel nonsense mutation in CRYGC in a Chinese family with autosomal dominant congenital nuclear cataracts and microcornea. METHODS We investigated a four-generation Chinese family with six members affected with nuclear cataracts and microcornea. The family resides in a relatively isolated region of northern China. Genomic DNA was isolated from blood l...

N-WASP regulates the actin cytoskeleton through activation of the Arp2/3 complex. N-WASP localizes at the cell periphery, where it controls actin polymerization downstream of signal molecules such as adapter proteins, Cdc42, Src family kinases, and phosphoinositides. N-WASP also localizes in the nucleus; however, the role of N-WASP in the nucleus is unclear. Here, we show that localization of N...

Plant FtsZ proteins are encoded by two small nuclear gene families (FtsZ1 and FtsZ2) and are involved in chloroplast division. From the moss Physcomitrella patens, four FtsZ proteins, two in each nuclear gene family, have been characterised and described so far. In the recently sequenced P. patens genome, we have now found a fifth ftsZ gene. This novel gene has a genomic structure similar to Pp...

background: the earlier atomic bomb explosion in hiroshima and nagasaki, and three worth mentioning nuclear accidents - detonation at fukushima daiichi nuclear plant, chernobyl nuclear fallout and an accident at three mile island nuclear power plant have made us more worried about the secure exploitation of nuclear energy. the central focus of this paper is to review radiation-mediated health e...

Nuclear factor of activated T cells-family proteins (NFAT1/NFATp, NFATc, NFAT3, and NFAT4/NFATx/NFATc3) play a key role in the transcription of cytokine genes and other genes during the immune response. We have defined the mechanisms of transactivation by NFAT1. NFAT1 possesses two transactivation domains whose sequences are not conserved in the other NFAT-family proteins, and a conserved DNA-b...