The RMA-S cell line was derived from the Raucher virus-induced murine cell line RBb5 by ethylmethane sulfonate mutagenesis and anti-H-2 antibody plus complement selection (Ljunggren, H.-G., and K. Karre. 1985.J. Exp. Med. 162:1745). RMA-S is defective in the ability to present endogenously synthesized antigens to class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes ...

The RMA-S cell line was derived from the Raucher virus-induced murine cell line RBb5 by ethylmethane sulfonate mutagenesis and anti-H-2 antibody plus complement selection (Ljunggren, H.-G., and K. Karre. 1985.J. Exp. Med. 162:1745). RMA-S is defective in the ability to present endogenously synthesized antigens to class I major histocompatibility complex (MHC)-restricted cytotoxic T lymphocytes ...

In this study, we examined the spread of SARS-CoV-2 infection and dose-dependent efficacy COVID-19 vaccine Covishield (Oxford/AstraZeneca). During period between December 2020 February 2021, tested level natural among individuals by estimating reactivity their sera towards spike (S) nucleoprotein (N) proteins.

1. Subjects recovered from SARS-CoV infection retain memory of cellular immune response to epitopes spanning over a few regions of the viral nucleoprotein. Ten such epitopes were identified. 2. The majority of epitopes were predominantly recognised by CD8+ cytotoxic T cells and elicited persistent memory response lasting at least 2 years. 3. There is potential to use the nucleoprotein of SARSCo...

Ebola virus is one of only two known members of a family of RNA viruses, the Filoviridae. (The other member is the Marburg virus.) The Filoviridae consists of enveloped viruses containing a non-segmented negative-stranded RNA genome. The Ebola genome shows a linear gene arrangement in the order 3' untranslated region -nucleoprotein (NP) -viral structural protein -(VP) 35 -VP40 -glycoprotein (GP...

The H-NS protein has emerged as one of the leading causes of transcriptional repression in Gram-negative bacteria. In a paper published in this issue, De la Cruz and colleagues shed new light on the role of DNA curvature in the repressive mechanism, using a porin gene promoter from the human pathogen Salmonella Typhi as their experimental system (De la Cruz et al., 2009). Their data help to dee...