Background: In the pathogenesis of inflammatory bowel disease (IBD), the advanced glycation end product receptor (RAGE) has been involved. IBD is classified into Chron’s disease (CD) and ulcerative colitis (UC). The promoter gene of the RAGE gene was discovered to have had unique polymorphisms that increased its transcriptional activity. This study, therefore, used a systematic review and meta-...

OBJECTIVE To explore the frequency and significance of ApoE gene polymorphisms in patients with sporadic Alzheimer's disease (AD). METHODS Single nucleotide polymorphisms of the ApoE gene were analyzed in 32 cases of AD and 26 controls, using PCR and gene sequencing. RESULTS The single nucleotide polymorphism of ApoE gene 462C/G was significantly associated with AD (P < 0.05). CONCLUSIONS...

Single-nucleotide polymorphisms are the largest source of genetic variation in humans. We report a method for the discovery of single-nucleotide polymorphisms within genomic DNA. Pooled genomic samples are amplified, denatured, and annealed to generate mismatches at polymorphic DNA sites. Upon photoactivation, these DNA mismatches are then cleaved site-specifically by using a small molecular pr...

Abstract Background Single-nucleotide polymorphisms (SNP) of the Nucleotide-binding oligomerization domain-containing protein 2 (NOD2) gene are associated with higher risk for Crohn′s disease (CD). It has also been reported that they more likely to associate specific phenotypes such as stricturing or perianal and need resection surgery. The aim our study was investigate if these NOD2 variants c...

Model selection procedures for simultaneous analysis of all single-nucleotide polymorphisms in genome-wide association studies are most suitable for making full use of the data for a complex disease study. In this paper we consider a penalized regression using the LASSO procedure and show that post-processing of the penalized-regression results with subsequent stepwise selection may lead to imp...

atopic dermatitis (ad) is a common chronically relapsing skin disease associated with abnormal cytokine production, and activation of t-helper 2 cells. the aim if this study was to determine whether cytokine gene polymorphisms might influence the development of ad. single nucleotide polymorphisms in the genes for i-l1alpha, il-1beta, il-1r, il-2, il-4, il-6, il-10, il-12, tgf beta, tnf and ifng...

Single-nucleotide polymorphisms, either inherited or due to spontaneous DNA damage, are associated with numerous diseases. Developing tools for site-specific nucleotide modification may one day provide a way to alter disease polymorphisms. Here, we describe the in vitro selection and characterization of a new deoxyribozyme called F-8, which catalyzes nucleotide excision specifically at thymidin...

Research has been conducted to identify sequence polymorphisms of gene promoter regions in patients and control subjects, including normal individuals, and to determine the influence of these polymorphisms on transcriptional regulation in cells that express wild-type or mutant p53. In this study we isolated genomic DNA from whole blood of healthy Japanese individuals and sequenced the promoter ...

We performed exome-wide association studies to identify genetic variants-in particular, low-frequency variants with a large effect size-that confer susceptibility to coronary artery disease or myocardial infarction in Japanese. The exome-wide association studies were performed with 12,698 individuals (3488 subjects with coronary artery disease including 2438 with myocardial infarction, 9210 con...

Abstract. Hatta ANNL, Sukma D, Maskromo I, Sudarsono S. 2023. Validated SNAP markers based on the CYP P450 87 A3 gene in coconut (Cocos nucifera) are associated with yearly stem height increase. Biodiversitas 24: 2503-2512. Tall and dwarf coconuts types used worldwide as parents hybrid production, they differ their height. The of is estimated 11 leaf scars length. essential stem-height increase...