Somatic mutations in the promoter region of human telomerase reverse transcriptase (hTERT) gene have been identified many types cancer. The hTERT is known to be enriched with sequences that enable formation G-quadruplex (G4) structures, whose presence associated elevated mutagenicity and genome instability. Here, we used a bioinformatics tool (QGRS mapper) search for G4-forming (G4 motifs) 1000...

Morris, George K. (University of Georgia, Athens), and William L. Williams. Inhibition of growth of Lactobacillus bulgaricus by purine deoxyribonucleotides. J. Bacteriol. 90:715-719. 1965.-An inhibition of growth of Lactobacillus bulgaricus GS was observed with deoxyadenylic acid and deoxyguanylic acid. Deoxynucleotides of cytosine, thymine, and uracil, and the deoxynucleosides of adenine, guan...

We analysed the secondary structure of two expansion segments (D2, D3) of the 28S rRNA gene from 229 leaf beetles (Coleoptera: Chrysomelidae), the majority of which are in the subfamily Galerucinae. The sequences were compared in a multiple sequence alignment, with secondary structure inferred primarily from the compensatory base changes in the conserved helices of the rRNA molecules. This comp...